Evidence map›Paper›PMID 39171167›Full record

ArticleWorld journal of gastrointestinal oncology2024

Application of fecal immunochemical test in colorectal cancer screening: A community-based, cross-sectional study in average-risk individuals in Hainan.

Fan Zeng, Da-Ya Zhang, Shi-Ju Chen, Run-Xiang Chen, Chen Chen, Shi-Mei Huang, Da Li, Xiao-Dong Zhang, Jia-Jia Chen, Cui-Yi Mo and 5 more

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In one paragraph

Article in World journal of gastrointestinal oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Fan ZengGraduate School, Hainan Medical University, Haikou 571199, Hainan Province, China.
Da-Ya ZhangGraduate School, Hainan Medical University, Haikou 571199, Hainan Province, China.
Shi-Ju ChenGraduate School, Hainan Medical University, Haikou 571199, Hainan Province, China.
Run-Xiang ChenGraduate School, Hainan Medical University, Haikou 571199, Hainan Province, China.
Chen ChenGraduate School, Hainan Medical University, Haikou 571199, Hainan Province, China.
Shi-Mei HuangGraduate School, Hainan Medical University, Haikou 571199, Hainan Province, China.
Da LiGraduate School, Hainan Medical University, Haikou 571199, Hainan Province, China.
Xiao-Dong ZhangGraduate School, Hainan Medical University, Haikou 571199, Hainan Province, China.
Jia-Jia ChenDepartment of Gastroenterology, Qionghai People's Hospital, Qionghai 571400, Hainan Province, China.
Cui-Yi MoDepartment of Gastroenterology, Qionghai People's Hospital, Qionghai 571400, Hainan Province, China.
Lei GaoDepartment of Gastroenterology, Sanya Central Hospital, Sanya 572022, Hainan Province, China.
Jun-Tao ZengDepartment of Gastroenterology, Sanya Central Hospital, Sanya 572022, Hainan Province, China.
Jian-Xin XiongDepartment of Gastroenterology, Hainan Second People's Hospital, Wuzhishang 572299, Hainan Province, China.
Zhai ChenDepartment of Gastroenterology, Dongfang People's Hospital, Dongfang 572699, Hainan Province, China.
Fei-Hu BaiDepartment of Gastroenterology, The Second Affiliated Hospital of Hainan Medical University, Haikou 570216, Hainan Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe incidence of colorectal cancer (CRC) in China is steadily rising, with a high proportion of advanced-stage diagnoses. This highlights the significance of early detection and prevention measures to enhance survival rates. Fecal immunochemical testing (FIT) is a globally recommended CRC screening method; however, limited research has been conducted on its application in Hainan.

aimTo assess the efficacy and adherence of FIT screening among average-risk individuals in Hainan, while also examining the risk factors associated with positive FIT results.

methodsThis population-based cross-sectional study implemented FIT screening for CRC in 2000 asymptomatic participants aged 40-75 years from five cities and 21 community health centers in Hainan Province. The study was conducted from August 2022 to April 2023, employing a stratified sampling method to select participants. Individuals with positive FIT results subsequently underwent colonoscopy. Positive predictive values for confirmed CRC and advanced adenoma were calculated, and the relationship between relevant variables and positive FIT results was analyzed using

resultsA total of 1788 participants completed the FIT screening, with a median age of 57 years (interquartile range: 40-75). Among them, 503 (28.1%) were males, and 1285 (71.9%) were females, resulting in an 89.4% compliance rate for FIT screening. The overall positivity rate of FIT was 4.4% [79 out of 1788; 95% confidence interval (CI): 3%-5%]. The specific positivity rates for Haikou, Sanya, Orient City, Qionghai City, and Wuzhishan City were 9.6% (45 of 468; 95%CI: 8%-11%), 1.3% (6 of 445; 95%CI: 0.1%-3.1%), 2.7% (8 of 293; 95%CI: 1.2%-4.3%), 3.3% (9 of 276; 95%CI: 1.0%-6.3%), and 4.2% (11 of 406; 95%CI: 1.2%-7.3%), respectively. Significant associations were found between age, dietary habits, and positive FIT results. Out of the 79 participants with positive FIT results, 55 underwent colonoscopy, demonstrating an 82.2% compliance rate. Among them, 10 had a clean gastrointestinal tract, 43 had polyps or adenomas, and 2 were confirmed to have CRC, yielding a positive predictive value of 3.6% (95%CI: 0.9%-4.2%). Among the 43 participants with polyps or adenomas, 8 were diagnosed with advanced adenomas, resulting in an advanced adenoma rate of 14.5% (95%CI: 10.1%-17.7%).

conclusionIn the Hainan region, FIT screening for CRC among asymptomatic individuals at average risk is feasible and well-received.

Indexed as

AdenomaColorectal cancerFecal immunochemical testHainan ProvinceScreening

Identifiers

PMID39171167
PMCPMC11334025

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.