ArticleOrganic process research & development2024
Continuous Flow Approach for Benzylic Photo-oxidations Using Compressed Air.
Article in Organic process research & development, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Insights into Flow and Continuous Systems in Pharmaceutical Manufacturing: Challenges and Opportunities.Organic process research & development · 2026Article
- A continuous flow process for the Ireland-Claisen rearrangement.RSC advances · 2025Article
- A Novel Double-Diamond Microreactor Design for Enhanced Mixing and Nanomaterial Synthesis.Micromachines · 2025Article
- Efficient photocatalytic reactorsRSC advances · 2025Article
- Continuous-flow-enabled intensification in nitration processes: a review of technological developments and practical applications over the past decade.Beilstein journal of organic chemistry · 2025Review
- Simultaneous reaction- and analytical model building using dynamic flow experiments to accelerate process development.Chemical science · 2024Article
- Visible-light-mediated flow protocol for Achmatowicz rearrangement.Beilstein journal of organic chemistry · 2024Article
- A field guide to flow chemistry for synthetic organic chemists.Chemical science · 2023Review
- Harnessing a Continuous-Flow Persulfuric Acid Generator for Direct Oxidative Aldehyde Esterifications.ChemSusChem · 2023Article
- Continuous Flow Biocatalytic Reductive Amination by Co-Entrapping Dehydrogenases with Agarose Gel in a 3D-Printed Mould Reactor.Chembiochem : a European journal of chemical biology · 2022Article
- Multistep Continuous Flow Synthesis of Isolable NHChemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Enantioselective Organophotocatalytic Telescoped Synthesis of a Chiral Privileged Active Pharmaceutical Ingredient.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Amide Bonds Meet Flow Chemistry: A Journey into Methodologies and Sustainable Evolution.ChemSusChem · 2022Review
- Study of the Pauson-Khand reaction in flow over alkynylphenyl vinyl ethers: towards the synthesis of tricyclic multisubstituted benzofurans.RSC advances · 2022Article
- An organophotocatalytic late-stage N-CHChemical science · 2022Article
- Continuous flow synthesis of Celecoxib from 2-bromo-3,3,3-trifluoropropene.Journal of flow chemistry · 2022Article
- Flow synthesis of oxadiazoles coupled with sequential in-line extraction and chromatography.Beilstein journal of organic chemistry · 2022Article
- Scaled up and telescoped synthesis of propofol under continuous-flow conditions.Journal of flow chemistry · 2022Article
- On drug discovery against infectious diseases and academic medicinal chemistry contributions.Beilstein journal of organic chemistry · 2022Article
- Cobalt catalysed aminocarbonylation of thiols in batch and flow for the preparation of amides.RSC advances · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A continuous flow approach for the aerobic photo-oxidation of benzylic substrates to ketone and aldehyde products is presented. The resulting process exploits UV-A LEDs (375 nm) in combination with a Corning AFR reactor that ensures effective gas-liquid mixing and leads to short residence times of 1 min. A variety of benzylic substrates are converted to their corresponding carbonyl products, and scalability is demonstrated to produce multigram quantities of products within a few hours. Overall, this continuous flow approach offers several improvements over alternative oxidation methods due to the combined use of air as an oxidant and SAS (sodium anthraquinone-2 sulfonate) as a water-soluble photocatalyst. The use of greener and safer conditions together with process intensification principles renders this flow approach attractive for further industrial applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.