ArticleARYA atherosclerosis
Cardioprotective effects of aerobic training in diabetic rats: Reducing cardiac apoptotic indices and oxidative stress for a healthier heart.
Article in ARYA atherosclerosis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Effects of High-Intensity Interval Training on Cardiometabolic Health in Children and Adolescents: A Systematic Review and Meta-Analysis.Journal of sports science & medicine · 2024Pooled it
- Unveiling Optimal Order of Power-Based Resistance and Short Sprint Interval Training in Maximizing Lower-Extremity Physical Fitness Attributes of Judo Athletes.Journal of sports science & medicine · 2026Trial
- Modified Sprint Interval Intervention Produces Lower Inter-Subject Variability in Physiological and Performance Adaptations Across Collegiate Soccer Players.Journal of sports science & medicine · 2025Trial
- Combined Vs. Single Supplementation of L-Citrulline and Sodium Bicarbonate During Sprint Interval Training in Basketball Players: Effects on Physical Performance and Hormonal Adaptations.Journal of sports science & medicine · 2025Trial
- Comparative analysis of consistency of adaptations to interval interventions individualized using sport-specific techniques in well-trained soccer players.Scientific reports · 2025Trial
- Daytime eccentric exercise and its impact on inflammatory markers and antioxidant defenses in physically active young men.Frontiers in immunology · 2025Trial
- Effects of Short Sprint Interval Training Frequency on Physical and Physiological Performance Adaptations in Male Soccer Players.Journal of sports science & medicine · 2024Trial
- Effects of Cluster vs. Traditional Sets Complex Training on Physical Performance Adaptations of Trained Male Volleyball Players.Journal of sports science & medicine · 2024Trial
- A Comparative Analysis of High-Intensity Technique-Specific Intervals and Short Sprint Interval Training in Taekwondo Athletes: Effects on Cardiorespiratory Fitness and Anaerobic Power.Journal of sports science & medicine · 2024Trial
- Effect of aerobic training on apoptosis biomarkers and cardiac wall stress in healthy and streptozotocin-induced diabetic male rats.American heart journal plus : cardiology research and practice · 2026Article
- Exercise-induced cardiac hypertrophy: cellular and molecular mechanisms of cardiac adaptation following physical activity.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2026Review
- Effects of weighted vestsFrontiers in physiology · 2026Article
- Swimming exercise improves vascular function and mitigates cardiac apoptotic response via Bcl-2 and Caspase-3 pathway in streptozotocin-induced diabetic rats: in vivo and in silico molecular docking study.European journal of medical research · 2025Article
- High-intensity interval training (HIIT) ameliorates cardiac hypertrophy and fibrosis in diabetic rats: the role of P53 and SIRT1.Journal of molecular histology · 2025Article
- Experimental Models of Type 2 Diabetes Mellitus Induced by Combining Hyperlipidemic Diet (HFD) and Streptozotocin Administration in Rats: An Integrative Review.Biomedicines · 2025Review
- Sequencing Effects of Concurrent Resistance and Short Sprint Interval Training on Physical Fitness, and Aerobic and Anaerobic Performance of Karate Athletes.Journal of sports science & medicine · 2025Article
- Aerobic Exercise and Metformin: A Dual Approach to Enhancing Glycemic Maintenance in Type 2 Diabetes Mellitus.Chonnam medical journal · 2025Review
- Comparative Effects of Exercise and GLP-1 RAs on Type 2 Diabetic Rat Model: A Systematic Review.International journal of exercise science · 2025Review
- Evaluation of the Effects ofInternational journal of endocrinology · 2025Article
- Similar adaptive responses in the upper body physical performance of table tennis players following the traditional and cluster set resistance and plyometric training.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe present study evaluated the effects of aerobic training with variable intensities on apoptotic indices of cardiac tissue in fatty diabetic rats.
methodsTwenty-four male Wistar rats were randomly divided into non-diabetic (ND, n=8), trained diabetic (TD, n=8), and control diabetic (CD, n=8) groups. Following a high-fat dietary regimen, type 2 diabetes was induced by streptozotocin, with blood glucose levels above 300 mg/dL considered indicative of diabetes. The TD group underwent aerobic exercise five times a week for six weeks. Subsequently, measurements were taken for left ventricular end-diastolic (LVEDV) and end-systolic volumes (LVESV), ejection fraction (EF%), catalase, caspase-9, P53, glucose, insulin, and HOMA-IR.
resultsAerobic training led to a significant decrease in blood glucose levels (P < 0.01), caspase-9 (P < 0.05), HOMA-IR (P < 0.05), and P53 expression (P < 0.001) compared with the CD group. LVEDV and LVESV decreased significantly (P < 0.05 for both), while LVEF increased significantly (P < 0.05). Catalase activation showed an insignificant increase in the TD group pre- to post-training compared to CD.
conclusionIncremental aerobic exercise training (6 weeks) may exert a cardioprotective effect in diabetic rats by reducing apoptosis and oxidative stress indices, while simultaneously increasing aerobic fitness and reducing body weight.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.