Evidence map›Paper›PMID 39170542›Full record

ArticleHeliyon2024

Sortilin is dispensable for secondary injury processes following traumatic brain injury in mice.

Irina Staib-Lasarzik, Christina Gölz, Wieslawa Bobkiewiecz, Pawit Somnuke, Anne Sebastiani, Serge C Thal, Michael K E Schäfer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Irina Staib-LasarzikDepartment of Anesthesiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Christina GölzDepartment of Anesthesiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Wieslawa BobkiewieczDepartment of Anesthesiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Pawit SomnukeDepartment of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.
Anne SebastianiDepartment of Anesthesiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Serge C ThalDepartment of Anesthesiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Michael K E SchäferDepartment of Anesthesiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traumatic brain injury (TBI) is characterized by complex secondary injury processes involving the p75 neurotrophin receptor (p75NTR), which has been proposed as a possible therapeutic target. However, the pathogenic role of the p75NTR co-receptor sortilin in TBI has not been investigated. In this study, we examined whether sortilin contributes to acute and early processes of secondary injury using a murine controlled cortical impact (CCI) model of TBI. Initial expression analysis showed a down-regulation of sortilin mRNA levels 1 and 5 day post injury (dpi) and a reduced expression of sortilin protein 1 dpi. Next, a total of 40 Sortilin

Identifiers

PMID39170542
PMCPMC11336488

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.