Evidence map›Paper›PMID 39170348›Full record

ReviewHeliyon2024

Collagen is crucial target protein for scleral remodeling and biomechanical change in myopia progression and control.

Yun Sun, Yaru Sha, Jing Yang, Hong Fu, Xinyu Hou, Zhuozheng Li, Yongfang Xie, Guohui Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. [Research progress and applications of biologically derived materials in scleral reconstruction].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
    Review
  4. Role of Autophagy in Scleral Remodeling During Form-Deprivation Myopia.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
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  13. FOXP4 Variants Are Associated With Plateau Iris and Angle Closure Glaucoma.Investigative ophthalmology & visual science · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yun SunSchool of Life Science and Technology, Shandong Second Medical University, Weifang, 261053, China.
Yaru ShaSchool of Life Science and Technology, Shandong Second Medical University, Weifang, 261053, China.
Jing YangSchool of Life Science and Technology, Shandong Second Medical University, Weifang, 261053, China.
Hong FuSchool of Life Science and Technology, Shandong Second Medical University, Weifang, 261053, China.
Xinyu HouSchool of Life Science and Technology, Shandong Second Medical University, Weifang, 261053, China.
Zhuozheng LiSchool of Life Science and Technology, Shandong Second Medical University, Weifang, 261053, China.
Yongfang XieSchool of Life Science and Technology, Shandong Second Medical University, Weifang, 261053, China.
Guohui WangSchool of Life Science and Technology, Shandong Second Medical University, Weifang, 261053, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent decades, the prevalence of myopia has been on the rise globally, attributed to changes in living environments and lifestyles. This increase in myopia has become a significant public health concern. High myopia can result in thinning of the sclera and localized ectasia of the posterior sclera, which is the primary risk factor for various eye diseases and significantly impacts patients' quality of life. Therefore, it is essential to explore effective prevention strategies and programs for individuals with myopia. Collagen serves as the principal molecule in the extracellular matrix (ECM) of scleral tissue, consisting of irregular collagen fibrils. Collagen plays a crucial role in myopia progression and control. During the development of myopia, the sclera undergoes a thinning process which is primarily influenced by collagen expression decreased and remodeled, thus leading to a decrease in its biomechanical properties. Improving collagen expression and promoting collagen crosslinking can slow down the progression of myopia. In light of the above, improving collagen expression or enhancing the mechanical properties of collagen fibers via medication or surgery represents a promising approach to control myopia.

Indexed as

BiomechanicsCollagenCollagen crosslinkingMyopiaSclera

Identifiers

PMID39170348
PMCPMC11336648

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.