Evidence map›Paper›PMID 39170210›Full record

ArticleHeliyon2024

Exploring Indonesian actinomycete extracts for anti-tubercular compounds: Integrating inhibition assessment, genomic analysis, and prediction of its target by molecular docking.

Arif Nurkanto, Masrukhin, Joseph Calvin Erdian Tampubolon, Muhammad Farrel Ewaldo, Ade Lia Putri, Shanti Ratnakomala, Ruby Setiawan, Ahmad Fathoni, Kartika Dyah Palupi, Yulia Rahmawati and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Arif NurkantoResearch Center for Biosystematics and Evolution, Research Organization for Life Sciences and Environmental, National Research and Innovation Agency (BRIN), West Java, Indonesia.
MasrukhinResearch Center for Biosystematics and Evolution, Research Organization for Life Sciences and Environmental, National Research and Innovation Agency (BRIN), West Java, Indonesia.
Joseph Calvin Erdian TampubolonDepartment of Biology, Faculty of Science and Mathematics, Diponegoro University, Central Java, Indonesia.
Muhammad Farrel EwaldoMaster's Programme in Biomedical Science, Faculty of Medicine, University of Indonesia, West Java, Indonesia.
Ade Lia PutriResearch Center for Biosystematics and Evolution, Research Organization for Life Sciences and Environmental, National Research and Innovation Agency (BRIN), West Java, Indonesia.
Shanti RatnakomalaResearch Center for Biosystematics and Evolution, Research Organization for Life Sciences and Environmental, National Research and Innovation Agency (BRIN), West Java, Indonesia.
Ruby SetiawanResearch Center for Biosystematics and Evolution, Research Organization for Life Sciences and Environmental, National Research and Innovation Agency (BRIN), West Java, Indonesia.
Ahmad FathoniResearch Center for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN), West Java, Indonesia.
Kartika Dyah PalupiResearch Center for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN), West Java, Indonesia.
Yulia RahmawatiResearch Center for Biosystematics and Evolution, Research Organization for Life Sciences and Environmental, National Research and Innovation Agency (BRIN), West Java, Indonesia.
Danang WaluyoResearch Center for Vaccine and Drug, Research Organization for Health, National Research and Innovation Agency (BRIN), Banten, Indonesia.
Erwahyuni Endang PrabandariResearch Center for Vaccine and Drug, Research Organization for Health, National Research and Innovation Agency (BRIN), Banten, Indonesia.
Sri PujiyantoDepartment of Biology, Faculty of Science and Mathematics, Diponegoro University, Central Java, Indonesia.
Yuji SumiiDepartment of Frontier Materials, Nagoya Institute of Technology, Nagoya, Japan.
Andria AgustaResearch Center for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN), West Java, Indonesia.
Norio ShibataDepartment of Frontier Materials, Nagoya Institute of Technology, Nagoya, Japan.
Sohkichi MatsumotoDepartment of Bacteriology, School of Medicine, Niigata University, Niigata, Japan.
Tomoyoshi NozakiGraduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tuberculosis (TB) is the foremost cause of infectious fatality globally. The primary global challenge in combatting TB lies in addressing the emergence of drug-resistant variants of the disease. However, the number of newly approved agents for treating TB has remained remarkably low over recent decades. Hence, research endeavors for discovering novel anti-TB agents are always needed. In the present study, we screened over 1,500 culture extracts from actinomycetes isolated in Indonesia for their inhibitory activity against

Indexed as

ActinomycetesActive compoundDocking studyExtractsScreeningShikimate kinaseTuberculosisWhole genome

Identifiers

PMID39170210
PMCPMC11336835

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.