Evidence map›Paper›PMID 39170007›Full record

ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2024

[Molecular Mechanism of circVRK1 Regulating the Proliferation and Apoptosis of Acute Lymphoblastic Leukemia KOCL44 Cells by Targeting miR-4428].

Huan Zhang, Bin Wu, Yuejiao Wang

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Huan Zhang（ 110004） Department of Hematology, Shengjing Hospital Affiliated to China Medical University, Shenyang 110004, China.
Bin Wu（ 110004） Department of Hematology, Shengjing Hospital Affiliated to China Medical University, Shenyang 110004, China.
Yuejiao Wang（ 110004） Department of Hematology, Shengjing Hospital Affiliated to China Medical University, Shenyang 110004, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To elucidate the role of circVRK1 and its interaction with miR-4428 in regulating proliferation and apoptosis in acute lymphoblastic leukemia (ALL) cells. Methods: KOCL44 ALL cells were cultured Results: Compared to the pcDNA group, circVRK1 expression was up-regulated in the pcDNA-circVRK1 group ( Conclusion: Overexpression of circVRK1 reduces the proliferation ability of acute ALL cells and induces cell apoptosis by downregulating miR-4428 expression.

Indexed as

ApoptosisCell ProliferationMicroRNAsPrecursor Cell Lymphoblastic Leukemia-LymphomaRNA, CircularCaspase 3Caspase 9Cell Line, TumorHumansCASP3 protein, humanCASP9 protein, humanCaspase 3Caspase 9MicroRNAsRNA, CircularAcute lymphocytic leukemiaCell apoptosisCell proliferationcircVRK1miR-4428

Identifiers

PMID39170007
PMCPMC11334292

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.