Evidence map›Paper›PMID 39169556›Full record

ArticleClinical pharmacology and therapeutics2024

Development of a Multifaceted Program for Pharmacogenetics Adoption at an Academic Medical Center: Practical Considerations and Lessons Learned.

Tyler Shugg, Emma M Tillman, Amy M Breman, Jennelle C Hodge, Christine A McDonald, Reynold C Ly, Elizabeth J Rowe, Wilberforce Osei, Tayler B Smith, Peter H Schwartz and 5 more

Abstract read
In one paragraph

Article in Clinical pharmacology and therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Evaluation of the Integration of Genetics and Genomics Into Nursing Practice.Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing · 2026
    Article
  4. Evaluation of CYP2C19 Clinical Decision Support Alerts to Guide P2YClinical pharmacology and therapeutics · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Tyler Shugg *Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0002-5784-3565
Emma M Tillman *Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0001-8019-9811
Amy M BremanDivision of Diagnostic Genomics, Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Jennelle C HodgeDivision of Diagnostic Genomics, Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0002-1770-4042
Christine A McDonaldDivision of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Reynold C LyDivision of Diagnostic Genomics, Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0002-3016-6859
Elizabeth J RoweDivision of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Wilberforce OseiDivision of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Tayler B SmithDivision of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Peter H SchwartzDivision of General Internal Medicine and Geriatrics, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
John T CallaghanDivision of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0001-7851-5651
Victoria M PrattDivision of Diagnostic Genomics, Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Sheryl LynchDivision of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Michael T Eadon *Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Todd C Skaar *Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Funding

Indiana Clinical and Translational Sciences InstituteUM1TR004402 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI Sharon M Moe, Sarah Elizabeth Wiehe · 2023 to 2026
$21.6M
Drug-gene-nutraceutical interactions of cannabidiolR01AT011463 · NCCIH · INDIANA UNIVERSITY INDIANAPOLIS · PI Michael Thomas Eadon · 2022 to 2026
$2.9M
Interdisciplinary Training in Cancer Prevention and ControlT32CA117865 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI Victoria Lee Champion, Catherine E Mosher · 2016 to 2026
$2.4M
Investigation of the Immune-Mediated Drug-Drug Interaction Potential of Immune Checkpoint InhibitorsK23GM147805 · NIGMS · INDIANA UNIVERSITY INDIANAPOLIS · PI Tyler A Shugg · 2022 to 2026
$836k
Acute inhibition of renal gene expression to prevent nephrotoxicity.K08DK107864 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI EADON, MICHAEL THOMAS · 2016 to 2020
$772k
IMSD at Indiana University School of Medicine through Inclusive Biomedical Research Training ProgramT32GM144891 · NIGMS · INDIANA UNIVERSITY INDIANAPOLIS · PI HURLEY, THOMAS D., YEH, ELIZABETH S · 2023 to 2024
$512k
HHS | NIH | National Cancer Institute (NCI): T32CA117865HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) K08DK107864HHS | NIH | National Institute of General Medical Sciences (NIGMS) K23GM147805HHS | NIH | National Institute of General Medical Sciences (NIGMS) T32GM144891Indiana UniversityNCATS NIH HHS UM1 TR004402NCCIH NIH HHS R01 AT011463NCI NIH HHS T32 CA117865NIDDK NIH HHS K08 DK107864NIGMS NIH HHS K23 GM147805NIGMS NIH HHS L30 GM151735NIGMS NIH HHS T32 GM144891
6 · The paper itself

Abstract

In 2019, Indiana University launched the Precision Health Initiative to enhance the institutional adoption of precision medicine, including pharmacogenetics (PGx) implementation, at university-affiliated practice sites across Indiana. The overarching goal of this PGx implementation program was to facilitate the sustainable adoption of genotype-guided prescribing into routine clinical care. To accomplish this goal, we pursued the following specific objectives: (i) to integrate PGx testing into existing healthcare system processes; (ii) to implement drug-gene pairs with high-level evidence and educate providers and pharmacists on established clinical management recommendations; (iii) to engage key stakeholders, including patients to optimize the return of results for PGx testing; (iv) to reduce health disparities through the targeted inclusion of underrepresented populations; (v) and to track third-party reimbursement. This tutorial details our multifaceted PGx implementation program, including descriptions of our interventions, the critical challenges faced, and the major program successes. By describing our experience, we aim to assist other clinical teams in achieving sustainable PGx implementation in their health systems.

Indexed as

Academic Medical CentersPharmacogeneticsPrecision MedicineHumansIndianaPharmacogenomic TestingProgram Development

Identifiers

PMID39169556
PMCPMC11452286

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.