Evidence map›Paper›PMID 39169435›Full record

ArticleScandinavian journal of trauma, resuscitation and emergency medicine2024

Hyperoxaemia in acute trauma is common and associated with a longer hospital stay: a multicentre retrospective cohort study.

Manuela Iten, Urs Pietsch, Juergen Knapp, Dominik Andreas Jakob, Gert Krummrey, Christian Maschmann, Jacob Steinmetz, Tobias Arleth, Martin Mueller, Wolf Hautz

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scandinavian journal of trauma, resuscitation and emergency medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Hypoxemia in trauma patients receiving two different oxygen strategies: a TRAUMOX2 substudy.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025
    Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Manuela ItenDepartment of Intensive Care Medicine, Inselspital, University Hospital Bern, Bern, Switzerland. manuela.iten@insel.ch.ORCID http://orcid.org/0000-0002-0140-2066
Urs PietschDivision of Perioperative Intensive Care Medicine, Cantonal Hospital St.Gallen, St. Gallen, Switzerland.
Juergen KnappSwiss Air Rescue, Rega, Zurich, Switzerland.
Dominik Andreas JakobDepartment of Emergency Medicine, Inselspital, University Hospital Bern, Bern, Switzerland.
Gert KrummreyInstitute for Medical Informatics I4MI, Bern University of Applied Sciences, Biel/Bienne, Switzerland.
Christian MaschmannDepartment of Emergency Medicine, Cantonal Hospital of St. Gallen, St. Gallen, Switzerland.
Jacob SteinmetzDepartment of Anaesthesia, Centre of Head and Orthopaedics, University of Copenhagen, Rigshospitalet, Denmark.
Tobias ArlethDepartment of Anaesthesia, Centre of Head and Orthopaedics, University of Copenhagen, Rigshospitalet, Denmark.
Martin Mueller *Department of Emergency Medicine, Inselspital, University Hospital Bern, Bern, Switzerland.
Wolf Hautz *Department of Emergency Medicine, Inselspital, University Hospital Bern, Bern, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTrauma poses a significant global health challenge. Despite advancements in the management of severely injured patients, (poly)trauma continues to be a primary contributor to morbidity and mortality worldwide. In the context of trauma resuscitation, supplemental oxygen is commonly administered generously as suggested by guidelines. Yet, it remains uncertain whether the trauma population might derive advantages from a more conservative approach to supplemental oxygen.

methodsIn this retrospective cohort study from two Swiss trauma centers, severely injured adult (> 16 years) trauma patients with an Injury Severity Score (ISS) ≥ 16 were divided into four groups according to the first blood gas analysis taken: hypoxaemia (PaO

resultsOf 1,189 trauma patients, 41.3% had hyperoxaemia (18.8% with severe hyperoxaemia) and 19.3% had hypoxaemia. No difference was found for 28-day mortality (hypoxaemia: 15.7%, normoxaemia: 14.1%, hyperoxaemia: 13.8%, severe hyperoxaemia: 16.0%, p = 0.846). Patients with severe hyperoxaemia had a significant prolonged LOS (median 12.5 [IQR 7-18.5] days vs. 10 [7-17], p = 0.040) and extended LOS-ICU (3.8 [1.8-9] vs. 2 [1-5] days, p = 0.149) compared to normoxaemic patients. In multivariable analysis, oxygen group was not associated with the primary outcome 28-day mortality or LOS-ICU. Severe hyperoxaemia patients had a tendency towards longer hospital stay (adjusted coefficient 2.23 days [95% CI: - 0.32; 4.79], p = 0.087).

conclusionHyperoxaemia was not associated with an increased 28-day mortality when compared to normoxaemia. However, both moderate and severe hyperoxaemia is frequently observed in trauma patients, and the presence of severe hyperoxaemia showed a tendency with extended hospital stay compared to normoxaemia patients. Robust randomized controlled trials are imperative to thoroughly evaluate the potential correlation between hyperoxaemia and outcomes in trauma patients . Trial Registration Retrospectively registered.

Indexed as

HyperoxiaLength of StayAdultBlood Gas AnalysisFemaleHumansInjury Severity ScoreMaleMiddle AgedOxygen Inhalation TherapyRetrospective StudiesSwitzerlandTrauma CentersWounds and InjuriesHyperoxaemiaHypoxaemiaNormoxaemiaOxygenTrauma

Identifiers

PMID39169435
PMCPMC11340037

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.