Evidence map›Paper›PMID 39169289›Full record

SynthesisBMC gastroenterology2024

Prevalence of autoimmune pancreatitis in pancreatic resection for suspected malignancy: a systematic review and meta-analysis.

Zain A Karamya, Attila Kovács, Dóra Illés, Bálint Czakó, Alíz Fazekas, Nelli Farkas, Péter Hegyi, László Czakó

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC gastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zain A KaramyaDivision of Gastroenterology, Department of Medicine, University of Szeged, Pf.: 427, Szeged, H-6701, Hungary.
Attila KovácsDepartment of Gastroenterology and Internal Medicine, Markusovszky Teaching Hospital, Szombathely, Hungary.
Dóra IllésDivision of Gastroenterology, Department of Medicine, University of Szeged, Pf.: 427, Szeged, H-6701, Hungary.
Bálint CzakóDivision of Gastroenterology, Department of Medicine, University of Szeged, Pf.: 427, Szeged, H-6701, Hungary.
Alíz FazekasInstitute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary.
Nelli FarkasInstitute of Bioanalysis, Medical School, University of Pécs, Pécs, Hungary.
Péter HegyiDivision of Pancreatic Diseases, Heart and Vascular Centre, Semmelweis University, Budapest, Hungary.
László CzakóDivision of Gastroenterology, Department of Medicine, University of Szeged, Pf.: 427, Szeged, H-6701, Hungary. czako.laszlo@med.u-szeged.hu.

Funding

Géza Hetényi Research Grant 5S 259New National Excellence Program of the Ministry of Human Capacities UNKP-22-2-SZTE-219Stipendium Hungaricum SHE-40894-004/2021the National Research, Development and Innovation Office K128222
6 · The paper itself

Abstract

BACKGROUND/

objectivesAutoimmune pancreatitis (AIP) is a diagnosis-challenging disease that often mimics pancreatic malignancy. Pancreatic resection is considered to be a curative treatment for pancreatic ductal adenocarcinoma (PDAC). This meta-analysis aims to study the incidence of AIP in patients who have undergone pancreatic resection for clinical manifestation of cancer.

methodsA comprehensive search was conducted in three databases, PubMed, Embase and the Cochrane Library, using the terms 'autoimmune pancreatitis' and 'pancreatic resection' and supplemented by manual checks of reference lists in all retrieved articles.

resultsTen articles were included in the final analysis. 8917 pancreatic resections were performed because of a clinical suspicion of pancreatic cancer. AIP accounted for 140 cases (1.6%). Type 1 AIP comprised the majority of cases, representing 94% (132 cases), while type 2 AIP made up the remaining 6% (eight cases) after further classification. AIP accounted for almost 26% of all cases of benign diseases involving unnecessary surgery and was overrepresented in males in 70% of cases compared to 30% in females. The mean age for AIP patients was 59 years. Serum CA 19 - 9 levels were elevated in 23 out of 47 (49%) AIP patients, where higher levels were detected more frequently in patients with type 1 AIP (51%, 22 out of 43) than in those with type 2 AIP (25%, 1 out of 4). The sensitivity of IgG4 levels in type 1 AIP was low (43%, 21/49 patients).

conclusionEven with modern diagnostic methods, distinguishing between AIP and PDAC can still be challenging, thus potentially resulting in unnecessary surgical procedures in some cases. Serum CA 19 - 9 levels are not useful in distinguishing between AIP and PDAC. Work must thus be done to improve diagnostic methods and avoid unnecessary complicated surgery.

Indexed as

Autoimmune PancreatitisCarcinoma, Pancreatic DuctalPancreatic NeoplasmsCA-19-9 AntigenDiagnosis, DifferentialFemaleHumansMaleMiddle AgedPancreatectomyPrevalenceCA-19-9 AntigenAutoimmune pancreatitisIgG4Pancreatic cancerPancreaticoduodenectomyPancreatic resectionWhipple’s procedure

Identifiers

PMID39169289
PMCPMC11337777

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.