Evidence map›Paper›PMID 39169193›Full record

ArticleNature2024

Catalytic asymmetric synthesis of meta benzene isosteres.

Mingkai Zhang, Matthew Chapman, Bhagyesh R Sarode, Bingcong Xiong, Hao Liang, James K Chen, Eranthie Weerapana, James P Morken

Abstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mingkai ZhangDepartment of Chemistry, Boston College, Chestnut Hill, MA, USA.ORCID http://orcid.org/0000-0001-5343-1742
Matthew ChapmanDepartment of Chemistry, Boston College, Chestnut Hill, MA, USA.ORCID http://orcid.org/0000-0001-6449-217X
Bhagyesh R SarodeDepartment of Chemical and Systems Biology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-9998-2451
Bingcong XiongDepartment of Chemistry, Boston College, Chestnut Hill, MA, USA.ORCID http://orcid.org/0009-0007-9602-5489
Hao LiangDepartment of Chemistry, Boston College, Chestnut Hill, MA, USA.
James K ChenDepartment of Chemical and Systems Biology, Stanford University, Stanford, CA, USA. jameschen@stanford.edu.ORCID http://orcid.org/0000-0002-9220-8436
Eranthie WeerapanaDepartment of Chemistry, Boston College, Chestnut Hill, MA, USA. eranthie.weerapana@bc.edu.ORCID http://orcid.org/0000-0002-0835-8301
James P MorkenDepartment of Chemistry, Boston College, Chestnut Hill, MA, USA. morken@bc.edu.ORCID http://orcid.org/0000-0002-9123-9791

Funding

Chemical tools for developmental biologyR35GM127030 · NIGMS · STANFORD UNIVERSITY · PI JAMES K CHEN · 2018 to 2026
$6.3M
New Strategies in Catalytic Organic Synthesis with Organoboron ReagentsR35GM127140 · NIGMS · BOSTON COLLEGE · PI JAMES Patrick MORKEN · 2018 to 2026
$5.1M
CryoProbe-enabled Bruker AVANCE NEO 500 MHz NMR SpectrometerS10OD026910 · OD · BOSTON COLLEGE · PI JAYASUNDERA, THUSITHA · 2021 to 2021
$1000k
Bruker D8 VENTURE DiffractometerS10OD030360 · OD · BOSTON COLLEGE · PI LI, BO · 2022 to 2022
$428k
Quantifying Horizontal Gene Transfer in the Human Gut MicrobiomeF32GM134694 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI RUBIN, BENJAMIN EMERY · 2019 to 2021
$195k
NIGMS NIH HHS F32 GM134694NIGMS NIH HHS R35 GM127030NIGMS NIH HHS R35 GM127140NIH HHS S10 OD026910NIH HHS S10 OD030360
6 · The paper itself

Abstract

Although aromatic rings are common elements in pharmaceutically active compounds, the presence of these motifs brings several liabilities with respect to the developability of a drug

Identifiers

PMID39169193
PMCPMC11878547

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.