Evidence map›Paper›PMID 39169188›Full record

ArticleNature2024

Prefrontal and lateral entorhinal neurons co-dependently learn item-outcome rules.

Heechul Jun, Jason Y Lee, Nicholas R Bleza, Ayana Ichii, Jordan D Donohue, Kei M Igarashi

Abstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Prefrontal Mechanisms of Rule Learning.bioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. Review
  10. Article
  11. Projection-specific Routing of Odor Information in the Olfactory Cortex.bioRxiv : the preprint server for biology · 2025
    Article
  12. Article
  13. Distinct brain regions map olfactory and visual spaces.bioRxiv : the preprint server for biology · 2025
    Article
  14. Article
  15. Article
  16. Lateral entorhinal cortex afferents reconfigure the activity in piriform cortex circuits.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Heechul Jun *Department of Anatomy and Neurobiology, School of Medicine, University of California Irvine, Irvine, CA, USA.ORCID 0000-0002-5905-2716
Jason Y Lee *Department of Anatomy and Neurobiology, School of Medicine, University of California Irvine, Irvine, CA, USA.ORCID 0000-0002-5670-7211
Nicholas R BlezaDepartment of Anatomy and Neurobiology, School of Medicine, University of California Irvine, Irvine, CA, USA.
Ayana IchiiDepartment of Anatomy and Neurobiology, School of Medicine, University of California Irvine, Irvine, CA, USA.ORCID 0009-0004-8219-8707
Jordan D DonohueDepartment of Anatomy and Neurobiology, School of Medicine, University of California Irvine, Irvine, CA, USA.ORCID 0000-0003-2997-5525
Kei M IgarashiDepartment of Anatomy and Neurobiology, School of Medicine, University of California Irvine, Irvine, CA, USA. kei.igarashi@uci.edu.ORCID 0000-0002-5635-169X

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008620 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI GOLDIN, ALAN L · 1999 to 2023
$8.1M
Understanding neural circuits for associative memory in the lateral entorhinal cortexR01MH121736 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI IGARASHI, KEI M · 2019 to 2023
$2.3M
Cell-type-specific vulnerability of the entorhinal cortex in Alzheimer's diseaseR01AG066806 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI IGARASHI, KEI M · 2020 to 2024
$2.0M
Understanding the role of gamma oscillations underlying entorhinal cortex dysfunction in Alzheimer’s diseaseR01AG063864 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI IGARASHI, KEI M · 2019 to 2023
$1.9M
Lateral entorhinal cortex dysfunction in an APP knock-in model of Alzheimer's diseaseR01AG086441 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Kei M Igarashi · 2024 to 2026
$1.6M
Circuit mechanisms underlying associative memory impairment in knock-in Alzheimer's modelF31AG074650 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI LEE, JASON YEN SUN · 2022 to 2023
$86k
Investigating spatial representation in hippocampal entorhinal circuit of knock in Alzheimer's modelF31AG069500 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI JUN, HEECHUL · 2020 to 2021
$75k
NIA NIH HHS F31 AG069500NIA NIH HHS F31 AG074650NIA NIH HHS R01 AG063864NIA NIH HHS R01 AG066806NIA NIH HHS R01 AG086441NIGMS NIH HHS T32 GM008620NIMH NIH HHS R01 MH121736
6 · The paper itself

Abstract

The ability to learn novel items depends on brain functions that store information about items classified by their associated meanings and outcomes

Indexed as

Entorhinal CortexLearningNeuronsPrefrontal CortexRewardAnimalsFemaleMaleMemoryMiceMice, Inbred C57BLOptogeneticsPunishment

Identifiers

PMID39169188
PMCPMC11484820

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.