ArticleNature2024
Stem cells tightly regulate dead cell clearance to maintain tissue fitness.
Abstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Tissue mitochondrial activity dictates the macrophage pool size.Science immunology · 2026Article
- Damage recognition by intestinal stem cells via Draper promotes adult Drosophila midgut regeneration.The EMBO journal · 2026Article
- Fuel to fire: developmental niche-empowered ApoEVs unlock adult hierarchical tissue regenerative potential via mitochondrial complex I-driven developmental metabolic profile.International journal of oral science · 2026Article
- Mitochondria-associated programmed cell death in pancreatic β cell of T2DM.Apoptosis : an international journal on programmed cell death · 2026Review
- Dying cells as architects of the stem cell niche: a conserved mechanism driving tissue regeneration and tumor therapy resistance.Cell communication and signaling : CCS · 2026Review
- Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity.Cell · 2026Article
- Immune Microenvironment of Hair Follicles in Tumor Immunotherapy.ImmunoTargets and therapy · 2026Review
- How stem cells respond to infection, inflammation and ageing.Nature reviews. Immunology · 2025Review
- New Fluorescent Synthetic Retinoids as Potential RAR Agonists with Anticancer, Molecular Docking and ADME Assessments.Journal of fluorescence · 2025Article
- Engineering Efferocytosis for Bone Regeneration.Macromolecular bioscience · 2025Review
- MSC-encapsulated porous microparticle eye drops for autoimmune dry eye disease treatment in NOD mice.Science advances · 2025Article
- Genome-wide association meta-regression identifies stem cell lineage orchestration as a key driver of acne risk.medRxiv : the preprint server for health sciences · 2025Article
- Nanobioreactor detection of space-associated hematopoietic stem and progenitor cell aging.Cell stem cell · 2025Article
- Ecdysone regulates phagocytic cell fate of epithelial cells in developing Drosophila eggs.The Journal of cell biology · 2025Article
- Deconstructing the Thymic Microenvironment Through Genesis to Senescence.Immunological reviews · 2025Review
- Reciprocal immune-epithelial interaction during breast cancer induction.Journal for immunotherapy of cancer · 2025Review
- Targeted self-assembled anti-NFκB AuNCs-aptamer nanoplatform for precise theranostics via tailored follicle regeneration.Materials today. Bio · 2025Article
- UTX (KDM6A) promotes differentiation noncatalytically in somatic self-renewing epithelia.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Aging and cell expansion enhance microRNA diversity in small extracellular vesicles produced from human adipose-derived stem cells.Cytotechnology · 2025Article
- Of Tingible Bodies and Starry Skies: Control of Normal and Malignant Tissues Through Apoptotic Cell-Dependent Communication (ACDC).Advances in experimental medicine and biology · 2025Review
Corrections and comments
- Update of
Authors and funding
16 authors.
Katherine S StewartHoward Hughes Medical Institute, Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY, USA. lab@kstewart.org.ORCID 0000-0003-3227-982X
Merve Deniz AbdusselamogluHoward Hughes Medical Institute, Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY, USA.ORCID 0000-0001-8467-3947
Matthew T TierneyHoward Hughes Medical Institute, Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY, USA.
Anita GolaHoward Hughes Medical Institute, Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY, USA.
Yun Ha HurHoward Hughes Medical Institute, Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY, USA.
Kevin A U GonzalesHoward Hughes Medical Institute, Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY, USA.
Shaopeng YuanHoward Hughes Medical Institute, Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY, USA.ORCID 0000-0001-9554-1325
Alain R BonnyHoward Hughes Medical Institute, Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY, USA.
Yihao YangHoward Hughes Medical Institute, Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY, USA.
Nicole R InfarinatoHoward Hughes Medical Institute, Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY, USA.
Christopher J CowleyHoward Hughes Medical Institute, Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY, USA.
John M LevorseHoward Hughes Medical Institute, Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY, USA.
Hilda Amalia PasolliElectron Microscopy Resource Center, The Rockefeller University, New York, NY, USA.ORCID 0000-0003-3899-3530
Sourav GhoshDepartments of Neurology and Pharmacology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-5990-8708
Carla V RothlinDepartments of Immunobiology and Pharmacology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-5693-5572
Elaine FuchsHoward Hughes Medical Institute, Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY, USA. fuchslb@rockefeller.edu.ORCID 0000-0002-0978-5137
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MVITAMIN A AND KERATINIZATION IN HUMAN EPITHELIAL CELLSR01AR031737 · NIAMS · UNIVERSITY OF CHICAGO · PI ELAINE FUCHS · 1986 to 2026
$16.6MGENE EXPRESSION AND DIFFERENTIATION IN HUMAN EPIDERMISR37AR027883 · NIAMS · UNIVERSITY OF CHICAGO · PI ELAINE FUCHS · 1994 to 2026
$13.3MSkin Stem Cells: Purification and CharacterizationR01AR050452 · NIAMS · ROCKEFELLER UNIVERSITY · PI ELAINE FUCHS · 2004 to 2026
$8.6MRestoring hair follicle stem cell fate and heterogeneity outside their native nicheK99AR079575 · NIAMS · ROCKEFELLER UNIVERSITY · PI TIERNEY, MATTHEW · 2022 to 2023
$223kDissecting the transcriptional mechanisms that govern melanocyte stem cell activationF31AR073110 · NIAMS · ROCKEFELLER UNIVERSITY · PI INFARINATO, NICOLE RAI · 2018 to 2020
$132kDissecting mechanisms of inflammation driven cancer susceptibility in epithelial barrier tissuesF99CA264439 · NCI · ROCKEFELLER UNIVERSITY · PI COWLEY, CHRISTOPHER · 2021 to 2022
$94kNCATS NIH HHS UL1 TR001863NCI NIH HHS F99 CA264439NIAMS NIH HHS F31 AR073110NIAMS NIH HHS K99 AR079575NIAMS NIH HHS R01 AR031737NIAMS NIH HHS R01 AR050452NIAMS NIH HHS R37 AR027883
Abstract
Billions of cells are eliminated daily from our bodies
Indexed as
ApoptosisHair FollicleHomeostasisPhagocytosisRegenerationStem CellsAnimalsFemaleLigandsLipid MetabolismMaleMicePhagocytesRetinoic Acid Receptor gammaRetinoidsRetinoid X Receptor alphaLigandsRarg protein, mouseRetinoic Acid Receptor gammaRetinoidsRetinoid X Receptor alphaRxra protein, mouse
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.