Evidence map›Paper›PMID 39169185›Full record

ArticleNature2024

Oligodendrocytes and myelin limit neuronal plasticity in visual cortex.

Wendy Xin, Megumi Kaneko, Richard H Roth, Albert Zhang, Sonia Nocera, Jun B Ding, Michael P Stryker, Jonah R Chan

Abstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. The Critical Period Microbiota Shape Brain Plasticity.bioRxiv : the preprint server for biology · 2026
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. The Fronto-Temporal Cortex Has Increased Subcortical Connectivity In Utero and Plasticity in Adulthood.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Wendy XinDepartment of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA. wen.xin@ucsf.edu.ORCID 0000-0002-1425-834X
Megumi KanekoDepartment of Physiology, Kavli Institute for Fundamental Neuroscience and Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Richard H RothDepartments of Neurosurgery and Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.ORCID 0000-0002-6855-999X
Albert ZhangDepartment of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Sonia NoceraDepartment of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Jun B DingDepartments of Neurosurgery and Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.ORCID 0000-0003-0690-1312
Michael P StrykerDepartment of Physiology, Kavli Institute for Fundamental Neuroscience and Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Jonah R ChanDepartment of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA. jonah.chan@ucsf.edu.ORCID 0000-0002-2176-1242

Funding

DEVELOPMENT &PLASTICITY OF THE VISUAL SYSTEMR01EY002874 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STRYKER, MICHAEL P · 1986 to 2022
$6.4M
Cell-type, circuit and network mechanisms of adult oligodendrogenesis in memory storage and retrievalR01MH125515 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAN, JONAH R, KHEIRBEK, MAZEN A · 2021 to 2025
$3.4M
Neuropeptides as axonal determinants for oligodendrocyte differentiation and myelinationR01NS115746 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAN, JONAH R · 2021 to 2025
$1.9M
Role of thalamic modulation in motor learningK99NS130078 · NINDS · STANFORD UNIVERSITY · PI ROTH, RICHARD · 2023 to 2024
$246k
Neuronal circuit modulation by myelination in the mammalian visual cortexK99NS131200 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI XIN, WEN · 2023 to 2024
$214k
Regulation of structural and functional neuronal plasticity by myelinationF32NS116214 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI XIN, WEN · 2020 to 2021
$164k
NEI NIH HHS R01 EY002874NIMH NIH HHS R01 MH125515NINDS NIH HHS F32 NS116214NINDS NIH HHS K99 NS130078NINDS NIH HHS K99 NS131200NINDS NIH HHS R01 NS115746
6 · The paper itself

Abstract

Developmental myelination is a protracted process in the mammalian brain

Indexed as

AgingMyelin SheathNeuronal PlasticityOligodendrogliaVisual CortexAnimalsCell DifferentiationDendritic SpinesFemaleMaleMiceSensory DeprivationSynaptic TransmissionVision, Monocular

Identifiers

PMID39169185
PMCPMC11424474

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.