ArticleNature2024
The periosteum provides a stromal defence against cancer invasion into the bone.
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Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
–field-weighted citation impact
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Who cites it
20 citing papers in PubMed.
- Multi-omic analysis of jaw-bone periosteum identifies the role of macrophage-derived SPP1 in CtskBone research · 2026Article
- An Injectable Magneto-Responsive Periosteum Reprograms Neutrophil Extracellular Trap Formation for Osteomyelitis Treatment.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Elevated IgG levels induce an M2‑to‑M1 phenotypic shift in mucosal macrophages and restrict the growth of invasive sphenoid sinus pituitary adenomas.Molecular medicine reports · 2026Article
- Development-based In Vivo Bioreactor Strategy for Challenging Senescent Bone Reconstruction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The Dual Roles of TIMP-1 in Cancer: From Protease Inhibition to Cytokine Signaling.Molecular biology reports · 2026Review
- Skeletal stem cell lineages in osteosarcoma and bone metastasis.Journal of bone and mineral metabolism · 2026Review
- Identification of core cytotoxic T lymphocyte-related subtypes, establishment of a prognostic model, and analysis tumor microenvironment infiltration in HNSC.Scientific reports · 2026Article
- A pan-cancer single-cell transcriptomic atlas of human bone metastases.Cell reports. Medicine · 2026Article
- Identification and validation of a novel ferroptosis-related gene signature associated with inherited retinal degeneration in Rd10 mice.Scientific reports · 2026Article
- Matrix Metalloproteinase-13 Is an Unfavorable Prognostic Factor in Chordoma by Digesting Growth Inhibitory Collagens.Cancer medicine · 2026Article
- Fibrous-layer periosteal stem cells sensing injury-induced inflammation.Cell research · 2026Article
- Stromal Defense Against Cancer: An Unprecedented Mechanism Limiting Cancer Invasion Into the Bone.Cancer science · 2026Review
- Endogenous Osteocyte-Osteoclast Signaling Enables Growth Factor-Free Bone Remodeling, Drug Response, and Cancer Invasion in a Nanoscale Calcified Bone-on-a-Chip Model.bioRxiv : the preprint server for biology · 2025Article
- The Periosteum in Health and Disease.Current osteoporosis reports · 2025Review
- Bone marrow endosteum in homeostasis and metastasis.Open biology · 2025Review
- Local abaloparatide administration promotes in situ alveolar bone augmentation via FAK-mediated periosteal osteogenesis.International journal of oral science · 2025Article
- Novel insights and recent progress in osteoimmunology.Trends in immunology · 2025Review
- Identification and function of periosteal skeletal stem cells in skeletal development, homeostasis, and disease.Journal of orthopaedic translation · 2025Review
- Bioinformatics Analysis and Identification of Ferroptosis-Related Gene TIMP1 as a Potential Biomarker of Asthma.Journal of inflammation research · 2025Article
- Editorial: Characterization and differential diagnosis of host immunity in patients with bone infections and bone tumors.Frontiers in immunology · 2024Article
Corrections and comments
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Authors and funding
20 authors.
Kazutaka NakamuraDepartment of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Masayuki TsukasakiDepartment of Osteoimmunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan. tsuka-im@m.u-tokyo.ac.jp.ORCID 0000-0001-7278-9643
Takaaki TsunematsuDepartment of Oral Molecular Pathology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Minglu YanDepartment of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.ORCID 0000-0002-5910-1266
Yutaro AndoDepartment of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.ORCID 0000-0002-1551-6419
Nam Cong-Nhat HuynhLaboratory of Oral-Maxillofacial Biology, Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam.ORCID 0000-0003-4718-7813
Kyoko HashimotoDepartment of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Qiao GouDepartment of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Ryunosuke MuroDepartment of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Ayumi ItabashiDepartment of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Takahiro IguchiDepartment of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.ORCID 0000-0003-2030-1145
Kazuo OkamotoDepartment of Osteoimmunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.ORCID 0000-0001-5855-5357
Takashi NakamuraDepartment of Biochemistry, Tokyo Dental College, Tokyo, Japan.ORCID 0000-0002-6124-061X
Kenta NakanoDepartment of Laboratory Animal Medicine, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.ORCID 0000-0003-2617-1468
Tadashi OkamuraDepartment of Laboratory Animal Medicine, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.ORCID 0000-0001-8457-1561
Tomoya UenoDepartment of Molecular Tumor Biology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Kosei ItoDepartment of Molecular Tumor Biology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.ORCID 0000-0002-8416-2466
Naozumi IshimaruDepartment of Oral Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Kazuto HoshiOral and Maxillofacial Surgery, Department of Sensory and Motor System Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Hiroshi TakayanagiDepartment of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan. takayana@m.u-tokyo.ac.jp.ORCID 0000-0002-1462-4127
Funding
Japan Agency for Medical Research and Development
Abstract
The periosteum is the layer of cells that covers nearly the entire surface of every bone. Upon infection, injury or malignancy the bone surface undergoes new growth-the periosteal reaction-but the mechanism and physiological role of this process remain unknown
Indexed as
Bone NeoplasmsHead and Neck NeoplasmsNeoplasm InvasivenessPeriosteumTissue Inhibitor of Metalloproteinase-1Tumor MicroenvironmentAnimalsDisease Models, AnimalFemaleHumansHypoxia-Inducible Factor 1, alpha SubunitMaleMiceSingle-Cell Gene Expression AnalysisSquamous Cell Carcinoma of Head and NeckStromal CellsHif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitTimp1 protein, mouseTissue Inhibitor of Metalloproteinase-1
Identifiers
PMID
39169177What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.