ArticleNature communications2024
Replay-triggered brain-wide activation in humans.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Efficacy and Safety of Mobile App-Based Metamemory Cognitive Training for Mild Cognitive Impairment: Multicenter Randomized Clinical Trial.JMIR mHealth and uHealth · 2026Trial
- Human brain-wide activation of sleep rhythms.eLife · 2026Article
- Article
- The default mode network: where spontaneous thought meets memory consolidation.Current opinion in behavioral sciences · 2026Article
- Conscious Initiation to Promote Physical Activity: A Behavioral Experiment and A Randomized Controlled Trial Intervention.International journal of behavioral medicine · 2026Article
- The effects of mirror visual feedback involved network priming on embodiment perception in healthy subjects: a proof-of-concept study.Frontiers in neuroscience · 2026Article
- Brain-wide resting-state fMRI network dynamics elicited by activation of single thalamic input.Nature communications · 2025Article
- Default mode network connectivity predicts individual differences in long-term forgetting: Evidence for storage degradation, not retrieval failure.PLoS computational biology · 2025Article
- Trait anxiety is associated with reduced reward-related replay at rest.Nature communications · 2025Article
- Time-dependent consolidation mechanisms of durable memory in spaced learning.Communications biology · 2025Article
- Sleep studies enter the real world.Nature human behaviour · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The consolidation of discrete experiences into a coherent narrative shapes the cognitive map, providing structured mental representations of our experiences. In this process, past memories are reactivated and replayed in sequence, fostering hippocampal-cortical dialogue. However, brain-wide engagement coinciding with sequential reactivation (or replay) of memories remains largely unexplored. In this study, employing simultaneous EEG-fMRI, we capture both the spatial and temporal dynamics of memory replay. We find that during mental simulation, past memories are replayed in fast sequences as detected via EEG. These transient replay events are associated with heightened fMRI activity in the hippocampus and medial prefrontal cortex. Replay occurrence strengthens functional connectivity between the hippocampus and the default mode network, a set of brain regions key to representing the cognitive map. On the other hand, when subjects are at rest following learning, memory reactivation of task-related items is stronger than that of pre-learning rest, and is also associated with heightened hippocampal activation and augmented hippocampal connectivity to the entorhinal cortex. Together, our findings highlight a distributed, brain-wide engagement associated with transient memory reactivation and its sequential replay.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.