Evidence map›Paper›PMID 39169055›Full record

ArticleScientific reports2024

Selective nanosecond laser removal of retinal pigment epithelium for cell therapy.

Van Phuc Nguyen, Athanasios J Karoukis, Justin Hu, Zhuying Wei, Dongshan Yang, Abigail T Fahim, Xueding Wang, Yannis M Paulus

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Long-Term Diabetic Retinopathy Treatment Using Silicon Nanoneedles.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Van Phuc NguyenDepartment of Ophthalmology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD, 21287, USA.
Athanasios J KaroukisDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, 48105, USA.
Justin HuDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, 48105, USA.
Zhuying WeiCenter for Advanced Models for Translational Sciences and Therapeutics, University of Michigan, Ann Arbor, MI, 48109, USA.
Dongshan YangCenter for Advanced Models for Translational Sciences and Therapeutics, University of Michigan, Ann Arbor, MI, 48109, USA.
Abigail T FahimDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, 48105, USA.
Xueding WangDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48105, USA.
Yannis M PaulusDepartment of Ophthalmology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD, 21287, USA. ypaulus1@jh.edu.

Funding

VIVARIUM MODULEP30EY007003 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI David Antonetti · 1987 to 2026
$17.6M
Multimodal Molecular Imaging of Choroidal NeovascularizationR01EY034325 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Yannis Mantas Paulus, XUEDING WANG · 2023 to 2026
$2.5M
Development of Nanoneedle Array for Painless and Long-Term Sustained Intraocular Drug DeliveryR01EY033000 · NEI · PURDUE UNIVERSITY · PI LEE, CHI HWAN, PAULUS, YANNIS MANTAS · 2021 to 2025
$1.9M
Real-time In Vivo Visualization of the Molecular Processes in Choroidal NeovascularizationK08EY027458 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PAULUS, YANNIS MANTAS · 2018 to 2021
$898k
Genome Editing Therapy for Usher Syndrome Type 3R42EY035582 · NEI · GENETOBE INC. · PI IANNUZZI, MICHAEL C, YANG, DONGSHAN · 2023 to 2023
$290k
Novel Nanosecond Laser and Ultrasound to Selectively Treat Eye Blood VesselsR41EY031219 · NEI · PHOTOSONOX LLC · PI PAULUS, YANNIS MANTAS · 2020 to 2020
$225k
NEI NIH HHS K08 EY027458NEI NIH HHS P30 EY007003NEI NIH HHS R01 EY033000NEI NIH HHS R01 EY034325NEI NIH HHS R41 EY031219NEI NIH HHS R42 EY035582NEI NIH HHS YMP:1K08EY027458
6 · The paper itself

Abstract

Retinal pigment epithelial (RPE) cells play a crucial role in the health of the retina, and their dysfunction is associated with various ocular diseases. The transplantation of RPE cells has been proposed as a potential treatment for numerous degenerative diseases, including geographic atrophy from macular degeneration. However, current models to induce RPE damage in animal models prior to transplantation involve mechanical scraping, chemical administration, or laser photocoagulation techniques, which can damage the overlying neurosensory retina. This study aims to investigate the feasibility and efficacy of nanosecond duration laser treatment to safely remove large areas of RPE cells without causing damage to the adjacent tissue or affecting the retinal architecture. Twelve pigmented rabbits were treated with a nanosecond laser on each eye at a laser energy ranging from 200 to 800 nJ with a treated area of 5 × 5 mm

Indexed as

Retinal Pigment EpitheliumAnimalsCell- and Tissue-Based TherapyCell DifferentiationFluorescein AngiographyHumansInduced Pluripotent Stem CellsLasersLaser TherapyRabbitsTomography, Optical Coherence

Identifiers

PMID39169055
PMCPMC11339075

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.