Evidence map›Paper›PMID 39168984›Full record

ArticleNature communications2024

Limb reduction in an Esco2 cohesinopathy mouse model is mediated by p53-dependent apoptosis and vascular disruption.

Arielle S Strasser, Ana Silvia Gonzalez-Reiche, Xianxiao Zhou, Braulio Valdebenito-Maturana, Xiaoqian Ye, Bin Zhang, Meng Wu, Harm van Bakel, Ethylin Wang Jabs

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Arielle S StrasserDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, USA.
Ana Silvia Gonzalez-ReicheDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, USA.ORCID 0000-0003-3583-4497
Xianxiao ZhouDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, USA.ORCID 0000-0001-9350-4467
Braulio Valdebenito-MaturanaDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, USA.ORCID 0000-0002-7361-2329
Xiaoqian YeDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, USA.
Bin ZhangDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, USA.
Meng WuDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, USA. wu.meng@mayo.edu.ORCID 0000-0001-5512-9651
Harm van BakelDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, USA. harm.vanbakel@mssm.edu.ORCID 0000-0002-1376-6916
Ethylin Wang JabsDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, USA. jabs.ethylin@mayo.edu.ORCID 0000-0001-8983-5466

Funding

Novel Network Biology Approaches to Reposition FDA-approved Drugs for Alzheimer's DiseaseR01AG068030 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BRENNAND, KRISTEN JENNIFER, CAI, DONGMING · 2020 to 2024
$4.2M
Transcriptome and Network Analysis of Cleft PalateR01DE029322 · NIDCR · MAYO CLINIC ROCHESTER · PI JABS, ETHYLIN WANG, VAN BAKEL, HARM · 2020 to 2024
$3.9M
Genetic, Tissue, and Anatomical Interactions in Mandibulofacial DysmorphogenesisR01DE029832 · NIDCR · MAYO CLINIC ROCHESTER · PI JABS, ETHYLIN WANG, KAWASAKI, KAZUHIKO · 2021 to 2024
$2.9M
Big Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0M
Multi-scale network biology approaches to analyze craniofacial expression dataR03DE026814 · NIDCR · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI JABS, ETHYLIN WANG, ZHANG, BIN · 2018 to 2019
$337k
NIA NIH HHS R01 AG068030NIDCR NIH HHS R01 DE029322NIDCR NIH HHS R01 DE029832NIDCR NIH HHS R03 DE026814NIH HHS S10 OD026880U.S. Department of Health & Human Services | National Institutes of Health (NIH) R03DE026814U.S. Department of Health & Human Services | National Institutes of Health (NIH) RO1AG068030U.S. Department of Health & Human Services | National Institutes of Health (NIH) S10OD026880
6 · The paper itself

Abstract

Roberts syndrome (RBS) is an autosomal recessive disorder with profound growth deficiency and limb reduction caused by ESCO2 loss-of-function variants. Here, we elucidate the pathogenesis of limb reduction in an Esco2

Indexed as

ApoptosisChromosomal Proteins, Non-HistoneCohesinsDisease Models, AnimalLimb Deformities, CongenitalTumor Suppressor Protein p53AnimalsBenzothiazolesCell Cycle CheckpointsCell Cycle ProteinsCraniofacial AbnormalitiesDNA DamageEctromeliaFemaleHemorrhageHomeodomain ProteinsBenzothiazolesCell Cycle ProteinsChromosomal Proteins, Non-HistoneCohesinsHomeodomain ProteinspifithrinPrrx1 protein, mouseTolueneTrp53 protein, mouseTumor Suppressor Protein p53

Identifiers

PMID39168984
PMCPMC11339411

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.