Evidence map›Paper›PMID 39168892›Full record

ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2024

Association between nutritional scores and multilevel vertebral involvement in tubercular spine: a retrospective cohort study.

Mantu Jain, Siddharth Satyakam Pradhan, Sujit Kumar Tripathy, Shahnawaz Khan, Suprava Naik, Baijayantimala Mishra

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Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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2 citing papers in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Mantu JainDepartment of Orthopedics, All India Institute of Medical Sciences, Bhubaneswar, 751019, Odisha, India.
Siddharth Satyakam PradhanDepartment of Orthopedics, All India Institute of Medical Sciences, Bhubaneswar, 751019, Odisha, India.
Sujit Kumar TripathyDepartment of Orthopedics, All India Institute of Medical Sciences, Bhubaneswar, 751019, Odisha, India. ortho_sujit@aiimsbhubaneswar.edu.in.ORCID http://orcid.org/0000-0003-0179-9910
Shahnawaz KhanDepartment of Orthopedics, All India Institute of Medical Sciences, Bhubaneswar, 751019, Odisha, India.
Suprava NaikDepartment of Radiology, AIIMS Bhubaneswar, Bhubaneswar, 751019, Odisha, India.
Baijayantimala MishraDepartment of Microbiology, AIIMS Bhubaneswar, Bhubaneswar, 751019, Odisha, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe objective of this study is to evaluate the prognostic value of nutritional scores comprising the Controlling Nutritional Status (CONUT) score and the Prognostic Nutritional Index (PNI), in prediction of multilevel vertebral involvement (> 2 vertebra) in Spinal Tuberculosis (STB).

methodsRetrospective analysis of 39 STB patients was conducted to assess nutritional indices (CONUT and PNI) and the numbers of vertebral affection. Spearman's correlation was used to examine the association between these variables. Receiver Operating Characteristic (ROC) curves were utilized to determine optimal cutoff values, with Area Under the Curve (AUROC) evaluation. Additionally, multiple logistic regression was performed as a predictive model.

resultsThere were 24 males and 15 females, with a mean BMI of 18.88 kg/m² (± 1.37). Spearman's correlation analysis revealed negative correlations between BMI, PNI (rho - 0.68, p < 0.001) and multilevel vertebra involvement, while ESR (rho 0.83, p < 0.001), CRP (rho 0.81, p < 0.001), and CONUT score (rho 0.83, p < 0.001) positively correlated with multilevel vertebral affection (> 2 vertebra). Age and comorbidities showed no correlation with the level of vertebral affection. ROC analysis revealed a CONUT Score ≥ 3 cutoff (sensitivity-95.7%, specificity-87.5%) and PNI ≤ 38.605 (sensitivity-78.3%, specificity-93.8%) for predicting multilevel STB (> 2). PNI exhibited superior specificity and positive predictive value where as CONUT score was a better parameter for sensitivity, negative predictive value and diagnostic accuracy. Both CONUT score and PNI were significant predictors of vertebral involvement in univariate analysis, with multivariate analysis identifying CONUT score as the sole predictor of multilevel vertebral affection.

conclusionNutritional scores, including CONUT score and PNI, emerged as significant predictors of multilevel STB. CONUT score displayed superior sensitivity, negative predictive value, and overall diagnostic accuracy, while PNI served as a nutritional marker with high specificity and positive predictive value in predicting multilevel involvement in spinal tuberculosis.

Indexed as

Nutritional StatusTuberculosis, SpinalAdultCohort StudiesFemaleHumansMaleMiddle AgedNutrition AssessmentPrognosisRetrospective StudiesROC CurveYoung AdultControlling nutritional statusMalnutritionNutritionPrognostic nutritional indexSpineTuberculosisUndernutrition

Identifiers

PMID39168892

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.