Evidence map›Paper›PMID 39168887›Full record

ArticleClinical and experimental nephrology2025

Children and adolescents with severe motor and intellectual disabilities who underwent kidney transplantation.

Ryo Nakatani, Kenichiro Miura, Taro Ando, Aya Kato, Yoko Shirai, Kiyonobu Ishizuka, Yuki Miyauchi, Daisuke Ogino, Yuko Akioka, Hideki Ishida and 1 more

Abstract read
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Article in Clinical and experimental nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Overcoming anatomical barriers in pediatric kidney transplantation.Pediatric nephrology (Berlin, Germany) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ryo NakataniDepartment of Pediatric Nephrology, Tokyo Women's Medical University, Tokyo, Japan.
Kenichiro MiuraDepartment of Pediatric Nephrology, Tokyo Women's Medical University, Tokyo, Japan.
Taro AndoDepartment of Pediatric Nephrology, Tokyo Women's Medical University, Tokyo, Japan.
Aya KatoDepartment of Pediatric Nephrology, Tokyo Women's Medical University, Tokyo, Japan.
Yoko ShiraiDepartment of Pediatric Nephrology, Tokyo Women's Medical University, Tokyo, Japan.
Kiyonobu IshizukaDepartment of Pediatric Nephrology, Tokyo Women's Medical University, Tokyo, Japan.
Yuki MiyauchiDepartment of Urology, Ehime University Graduate School of Medicine, Ehime, Japan.
Daisuke OginoDepartment of Pediatrics, Yamagata University School of Medicine, Yamagata, Japan.
Yuko AkiokaDepartment of Pediatrics, Saitama Medical University, Saitama, Japan.
Hideki IshidaDepartment of Organ Transplant Medicine, Tokyo Women's Medical University, Tokyo, Japan.
Motoshi HattoriDepartment of Pediatric Nephrology, Tokyo Women's Medical University, Tokyo, Japan. hattori.motoshi@twmu.ac.jp.ORCID http://orcid.org/0000-0002-4309-8672

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundKidney transplantation (KT) in children and adolescents with severe motor and intellectual disabilities (SMID) has been a topic of controversy. A multicenter study in Japan showed that KT was not contraindicated for children with multiple handicaps, but no consensus has been reached on KT for patients with SMID. This study aimed to determine whether KT is a viable treatment option for children and adolescents with SMID.

methodsA single-center, retrospective study was conducted on children and adolescents with SMID who underwent KT. SMID was defined based on Oshima's classification. Clinical information was collected through a review of medical records.

resultsOf 453 children and adolescents who underwent KT between 1983 and 2023 in our institution, six (1.3%) patients with SMID were identified. One patient received KT twice. All patients underwent living KT. Five patients used medical devices, including gastrostomy and a ventriculoperitoneal shunt, prior to KT. Perioperative complications, including hemothorax related to central venous catheter insertion, ventilator-associated pneumonia, and common iliac artery thrombosis requiring graftectomy, occurred in three patients. One patient required vesicostomy owing to refractory urinary tract infection. There was no significant difference in the graft survival rate between patients with SMID and those without SMID. One patient developed graft failure and died after selecting conservative kidney management.

conclusionOur study showed a favorable graft survival in children and adolescents with SMID who underwent KT. Although careful perioperative management and continued medical care are required, KT may be a viable option for these patients.

Indexed as

Intellectual DisabilityKidney Failure, ChronicKidney TransplantationMotor DisordersAdolescentChildChild, PreschoolFemaleGraft SurvivalHumansJapanMalePostoperative ComplicationsRetrospective StudiesSeverity of Illness IndexTreatment OutcomeChildren and adolescentsGraft survivalKidney transplantationMedical careSevere motor and intellectual disabilities

Identifiers

PMID39168887

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.