Evidence map›Paper›PMID 39168829›Full record

ArticleAngewandte Chemie (International ed. in English)2024

Gas Tunnel Engineering of Prolyl Hydroxylase Reprograms Hypoxia Signaling in Cells.

Peter Windsor, Haiping Ouyang, Joseph A G da Costa, Anoop Rama Damodaran, Yue Chen, Ambika Bhagi-Damodaran

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Capturing Fast Gas Migration in Proteins.Molecules (Basel, Switzerland) · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Oxygen sensing and plant adaptation to flooding in a changing climate.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Peter WindsorDepartment of Chemistry, University of Minnesota, Twin Cities, Minneapolis, MN 55455, United States.
Haiping OuyangDepartment of Biochemistry and Molecular Biology, University of Minnesota, Twin Cities, Minneapolis, MN 55455, United States.
Joseph A G da CostaDepartment of Chemistry, University of Minnesota, Twin Cities, Minneapolis, MN 55455, United States.
Anoop Rama DamodaranDepartment of Chemistry, University of Minnesota, Twin Cities, Minneapolis, MN 55455, United States.
Yue ChenDepartment of Biochemistry and Molecular Biology, University of Minnesota, Twin Cities, Minneapolis, MN 55455, United States.
Ambika Bhagi-DamodaranDepartment of Chemistry, University of Minnesota, Twin Cities, Minneapolis, MN 55455, United States.ORCID 0000-0002-4901-074X

Funding

Functional Dissection of Metabolic-Sensing Proline Hydroxylation PathwaysR35GM124896 · NIGMS · UNIVERSITY OF MINNESOTA · PI Yue Chen · 2017 to 2026
$3.1M
Decoding and Rewiring Enzymatic Redox Signal Transduction PathwaysR35GM138277 · NIGMS · UNIVERSITY OF MINNESOTA · PI Ambika Bhagi · 2020 to 2026
$2.6M
NIGMS NIH HHS R35 GM124896NIGMS NIH HHS R35 GM138277NIH NIGMS R35GM124896NIH NIGMS R35GM138277NSF CHE-1753154
6 · The paper itself

Abstract

Cells have evolved intricate mechanisms for recognizing and responding to changes in oxygen (O

Indexed as

Signal TransductionCell HypoxiaHEK293 CellsHumansHypoxia-Inducible Factor-Proline DioxygenasesOxygenProcollagen-Proline DioxygenaseProtein EngineeringEGLN1 protein, humanHypoxia-Inducible Factor-Proline DioxygenasesOxygenProcollagen-Proline Dioxygenasecellular signalinggas tunnelsnon-heme ironoxygen sensingprotein design

Identifiers

PMID39168829
PMCPMC11701916

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.