ArticleMolecular pharmacology2024
The Estrogen Receptor-Related Orphan Receptors Regulate Autophagy through TFEB.
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Article in Molecular pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6citing papers in PubMed
–field-weighted citation impact
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Exercise-Induced Regulation of Bone Remodeling via Mitophagy: A Review of Current Evidence.Biomolecules · 2026Review
- Acidosis, Iron Dyshomeostasis and Inflammatory Injury.International journal of molecular sciences · 2026Review
- Role of nuclear receptors, lipid metabolism, and mitochondrial function in the pathogenesis of diabetic kidney disease.American journal of physiology. Renal physiology · 2025Review
- Programmed Cell Death in Heart Failure: Mechanisms, Impacts, and Therapeutic Prospects.Reviews in cardiovascular medicine · 2025Review
- Targeting lipophagy and nuclear receptors in metabolic-associated fatty liver disease: insights from traditional Chinese medicine.Frontiers in pharmacology · 2025Review
- The Estrogen Receptor-Related Orphan Receptors Regulate Autophagy through TFEB.Molecular pharmacology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
McKenna LosbyDivision of Biology & Biomedical Sciences, Washington University School of Medicine, St. Louis (M.L.); Department of Pharmacodynamics, University of Florida College of Pharmacy, Gainesville, Florida (M.H., A.V., R.S., T.P.B.); University of Florida Genetics Institute, Gainesville, Florida (T.P.B.); Brown Foundation Institute of Molecular Medicine, McGovern Medical School, UTHealth, Houston, Texas, (D.H.S., V.A.N.); Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, Missouri (J.K.W.); Department of Molecular and Human Genetics, Baylor College of Medicine, Houston TX (W.X., L.Z.); and Center for Clinical Pharmacology, St Louis College of Pharmacy, University of Health Sciences and Pharmacy, St. Louis MO (C.B.).
Matthew HayesDivision of Biology & Biomedical Sciences, Washington University School of Medicine, St. Louis (M.L.); Department of Pharmacodynamics, University of Florida College of Pharmacy, Gainesville, Florida (M.H., A.V., R.S., T.P.B.); University of Florida Genetics Institute, Gainesville, Florida (T.P.B.); Brown Foundation Institute of Molecular Medicine, McGovern Medical School, UTHealth, Houston, Texas, (D.H.S., V.A.N.); Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, Missouri (J.K.W.); Department of Molecular and Human Genetics, Baylor College of Medicine, Houston TX (W.X., L.Z.); and Center for Clinical Pharmacology, St Louis College of Pharmacy, University of Health Sciences and Pharmacy, St. Louis MO (C.B.).
Aurore ValfortDivision of Biology & Biomedical Sciences, Washington University School of Medicine, St. Louis (M.L.); Department of Pharmacodynamics, University of Florida College of Pharmacy, Gainesville, Florida (M.H., A.V., R.S., T.P.B.); University of Florida Genetics Institute, Gainesville, Florida (T.P.B.); Brown Foundation Institute of Molecular Medicine, McGovern Medical School, UTHealth, Houston, Texas, (D.H.S., V.A.N.); Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, Missouri (J.K.W.); Department of Molecular and Human Genetics, Baylor College of Medicine, Houston TX (W.X., L.Z.); and Center for Clinical Pharmacology, St Louis College of Pharmacy, University of Health Sciences and Pharmacy, St. Louis MO (C.B.).
Danesh H SopariwalaDivision of Biology & Biomedical Sciences, Washington University School of Medicine, St. Louis (M.L.); Department of Pharmacodynamics, University of Florida College of Pharmacy, Gainesville, Florida (M.H., A.V., R.S., T.P.B.); University of Florida Genetics Institute, Gainesville, Florida (T.P.B.); Brown Foundation Institute of Molecular Medicine, McGovern Medical School, UTHealth, Houston, Texas, (D.H.S., V.A.N.); Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, Missouri (J.K.W.); Department of Molecular and Human Genetics, Baylor College of Medicine, Houston TX (W.X., L.Z.); and Center for Clinical Pharmacology, St Louis College of Pharmacy, University of Health Sciences and Pharmacy, St. Louis MO (C.B.).
Ryan SandersDivision of Biology & Biomedical Sciences, Washington University School of Medicine, St. Louis (M.L.); Department of Pharmacodynamics, University of Florida College of Pharmacy, Gainesville, Florida (M.H., A.V., R.S., T.P.B.); University of Florida Genetics Institute, Gainesville, Florida (T.P.B.); Brown Foundation Institute of Molecular Medicine, McGovern Medical School, UTHealth, Houston, Texas, (D.H.S., V.A.N.); Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, Missouri (J.K.W.); Department of Molecular and Human Genetics, Baylor College of Medicine, Houston TX (W.X., L.Z.); and Center for Clinical Pharmacology, St Louis College of Pharmacy, University of Health Sciences and Pharmacy, St. Louis MO (C.B.).
John K WalkerDivision of Biology & Biomedical Sciences, Washington University School of Medicine, St. Louis (M.L.); Department of Pharmacodynamics, University of Florida College of Pharmacy, Gainesville, Florida (M.H., A.V., R.S., T.P.B.); University of Florida Genetics Institute, Gainesville, Florida (T.P.B.); Brown Foundation Institute of Molecular Medicine, McGovern Medical School, UTHealth, Houston, Texas, (D.H.S., V.A.N.); Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, Missouri (J.K.W.); Department of Molecular and Human Genetics, Baylor College of Medicine, Houston TX (W.X., L.Z.); and Center for Clinical Pharmacology, St Louis College of Pharmacy, University of Health Sciences and Pharmacy, St. Louis MO (C.B.).
Weiyi XuDivision of Biology & Biomedical Sciences, Washington University School of Medicine, St. Louis (M.L.); Department of Pharmacodynamics, University of Florida College of Pharmacy, Gainesville, Florida (M.H., A.V., R.S., T.P.B.); University of Florida Genetics Institute, Gainesville, Florida (T.P.B.); Brown Foundation Institute of Molecular Medicine, McGovern Medical School, UTHealth, Houston, Texas, (D.H.S., V.A.N.); Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, Missouri (J.K.W.); Department of Molecular and Human Genetics, Baylor College of Medicine, Houston TX (W.X., L.Z.); and Center for Clinical Pharmacology, St Louis College of Pharmacy, University of Health Sciences and Pharmacy, St. Louis MO (C.B.).
Vihang A NarkarDivision of Biology & Biomedical Sciences, Washington University School of Medicine, St. Louis (M.L.); Department of Pharmacodynamics, University of Florida College of Pharmacy, Gainesville, Florida (M.H., A.V., R.S., T.P.B.); University of Florida Genetics Institute, Gainesville, Florida (T.P.B.); Brown Foundation Institute of Molecular Medicine, McGovern Medical School, UTHealth, Houston, Texas, (D.H.S., V.A.N.); Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, Missouri (J.K.W.); Department of Molecular and Human Genetics, Baylor College of Medicine, Houston TX (W.X., L.Z.); and Center for Clinical Pharmacology, St Louis College of Pharmacy, University of Health Sciences and Pharmacy, St. Louis MO (C.B.).
Lilei ZhangDivision of Biology & Biomedical Sciences, Washington University School of Medicine, St. Louis (M.L.); Department of Pharmacodynamics, University of Florida College of Pharmacy, Gainesville, Florida (M.H., A.V., R.S., T.P.B.); University of Florida Genetics Institute, Gainesville, Florida (T.P.B.); Brown Foundation Institute of Molecular Medicine, McGovern Medical School, UTHealth, Houston, Texas, (D.H.S., V.A.N.); Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, Missouri (J.K.W.); Department of Molecular and Human Genetics, Baylor College of Medicine, Houston TX (W.X., L.Z.); and Center for Clinical Pharmacology, St Louis College of Pharmacy, University of Health Sciences and Pharmacy, St. Louis MO (C.B.).
Cyrielle BillonDivision of Biology & Biomedical Sciences, Washington University School of Medicine, St. Louis (M.L.); Department of Pharmacodynamics, University of Florida College of Pharmacy, Gainesville, Florida (M.H., A.V., R.S., T.P.B.); University of Florida Genetics Institute, Gainesville, Florida (T.P.B.); Brown Foundation Institute of Molecular Medicine, McGovern Medical School, UTHealth, Houston, Texas, (D.H.S., V.A.N.); Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, Missouri (J.K.W.); Department of Molecular and Human Genetics, Baylor College of Medicine, Houston TX (W.X., L.Z.); and Center for Clinical Pharmacology, St Louis College of Pharmacy, University of Health Sciences and Pharmacy, St. Louis MO (C.B.).
Thomas P BurrisDivision of Biology & Biomedical Sciences, Washington University School of Medicine, St. Louis (M.L.); Department of Pharmacodynamics, University of Florida College of Pharmacy, Gainesville, Florida (M.H., A.V., R.S., T.P.B.); University of Florida Genetics Institute, Gainesville, Florida (T.P.B.); Brown Foundation Institute of Molecular Medicine, McGovern Medical School, UTHealth, Houston, Texas, (D.H.S., V.A.N.); Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, Missouri (J.K.W.); Department of Molecular and Human Genetics, Baylor College of Medicine, Houston TX (W.X., L.Z.); and Center for Clinical Pharmacology, St Louis College of Pharmacy, University of Health Sciences and Pharmacy, St. Louis MO (C.B.) Burris.thomas@ufl.edu.
Funding
Exercise Mimetics for Dementia and Alzheimer's DiseaseRF1AG077160 · NIA · UNIVERSITY OF FLORIDA · PI BURRIS, THOMAS P, ELGENDY, BAHAA · 2023 to 2023
$2.3MNew therapeutic strategies for Peripheral Arterial DiseaseR01HL152108 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI NARKAR, VIHANG A · 2021 to 2024
$1.8MNHLBI NIH HHS R01 HL152108NIA NIH HHS RF1 AG077160
Abstract
Autophagy is an essential self-degradative and recycling mechanism that maintains cellular homeostasis. Estrogen receptor-related orphan receptors (ERRs) are fundamental in regulating cardiac metabolism and function. Previously, we showed that ERR agonists improve cardiac function in models of heart failure and induce autophagy. Here, we characterized a mechanism by which ERRs induce the autophagy pathway in cardiomyocytes. Transcription factor EB (TFEB) is a master regulator of the autophagy-lysosome pathway and has been shown to be crucial regulator of genes that control autophagy. We discovered that TFEB is a direct ERR target gene whose expression is induced by ERR agonists. Activation of ERR results in increased TFEB expression in both neonatal rat ventricular myocytes and C
Indexed as
AutophagyBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsMyocytes, CardiacReceptors, EstrogenAnimalsCell LineERRalpha Estrogen-Related ReceptorHumansMiceRatsRats, Sprague-DawleyBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsERRalpha Estrogen-Related ReceptorReceptors, EstrogenTcfeb protein, mouseTFEB protein, rat
Identifiers
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Textmetadata
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.