Evidence map›Paper›PMID 39168311›Full record

ReviewJournal of the American Academy of Dermatology2025

The human skin microbiome in health.

Margaret A MacGibeny, Susuana Adjei, Hunter Pyle, Christopher G Bunick, Mahmoud Ghannoum, Ayman Grada, Tamia Harris-Tryon, Stephen K Tyring, Heidi H Kong

Abstract readReview
In one paragraph

Review in Journal of the American Academy of Dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Margaret A MacGibenyDepartment of Dermatology, Yale School of Medicine, New Haven, Connecticut.
Susuana AdjeiDepartment of Dermatology, Lake Granbury Medical Center, Dallas, Texas.
Hunter PyleDepartment of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas.
Christopher G BunickDepartment of Dermatology, Yale School of Medicine, New Haven, Connecticut; Program in Translational Biomedicine, Yale School of Medicine, New Haven, Connecticut.
Mahmoud GhannoumIntegrated Microbiome Core and Center for Medical Mycology, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, Ohio; Department of Dermatology, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Ayman GradaIntegrated Microbiome Core and Center for Medical Mycology, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Tamia Harris-TryonDepartment of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas.
Stephen K TyringDepartment of Dermatology, Center for Clinical Studies, McGovern School of Medicine, University of Texas Health Science Center, Houston, Texas. Electronic address: styring@ccstexas.com.
Heidi H KongDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland. Electronic address: konghe@mail.nih.gov.

Funding

Studies of human microbes and potential perturbationsZIAAR041219 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI KONG, HEIDI · 2022 to 2025
$4.3M
Studies of Skin Microflora in Healthy Individuals and Atopic Dermatitis PatientsZIAAR041217 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI KONG, HEIDI · 2022 to 2023
$1.2M
Intramural NIH HHS Z99 AR999999Intramural NIH HHS ZIA AR041217
6 · The paper itself

Abstract

Human skin is home to a myriad of microorganisms, including bacteria, viruses, fungi, and mites, many of which are considered commensal microbes that aid in maintaining the overall homeostasis or steady-state condition of the skin and contribute to skin health. Our understanding of the complexities of the skin's interaction with its microorganisms is evolving. This knowledge is based primarily on in vitro and animal studies, and more work is needed to understand how this knowledge relates to humans. Here, we introduce the concept of the skin microbiome and discuss skin microbial ecology, some intrinsic factors with potential influence on the human skin microbiome, and possible microbiome-host interactions. The second article of this two-part CME series describes how microbiome alterations may be associated with skin disease, how medications can affect the microbiome, and what microbiome-based therapies are under investigation.

Indexed as

MicrobiotaSkinSkin DiseasesHost Microbial InteractionsHumansSkin Microbiomecutaneous and pilosebaceous ecologymicrobial and host interactionsmicrobiotaskin microbiome

Identifiers

PMID39168311
PMCPMC11912297

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.