ArticleThe Journal of allergy and clinical immunology2024
Indoor allergen exposure and its association to upper respiratory infections and pulmonary outcomes among children with asthma.
Article in The Journal of allergy and clinical immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Rental housing may contribute to racial and ethnic disparities in upper respiratory infections.medRxiv : the preprint server for health sciences · 2026Article
- Cat exposure and asthma outcomes in a cohort of children with asthma and allergy.Frontiers in allergy · 2026Article
- Neighborhood disadvantage and the back-to-school epidemic of viral-associated asthma exacerbations.The Journal of allergy and clinical immunology · 2025Article
- The Impact of the Indoor Environment on Childhood Asthma.Current allergy and asthma reports · 2025Review
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Authors and funding
10 authors.
Funding
Abstract
backgroundCertain environmental allergen exposures are more common in disadvantaged communities and may contribute to differences in susceptibility to upper respiratory infections (URIs).
objectivesWe examined associations between indoor allergens and: (1) URI; (2) URI + cold symptoms; (3) URI + cold symptoms + pulmonary eosinophilic inflammation (fraction of exhaled nitric oxide ≥20 ppb); and (4) URI + cold symptoms + reduced lung function (percent predicted forced expiratory volume in 1 second of <80%).
methodsWe used data from the Environmental Control as Add-on Therapy for Childhood Asthma (ECATCh) study. Allergen concentrations were measured in air (mouse) and settled dust (mouse, cockroach, dog, and cat). URI was determined by testing nasal mucus for upper respiratory viruses. We evaluated associations between allergen concentrations and URI-associated outcomes accounting for age, sex, study month, season, health insurance, and household size.
resultsNinety participants (92% Black, 92% public insurance) with 192 observations were included; 52 (27%) of observations were positive for URI. A doubling in cockroach allergen concentration increased the odds of a URI with cold symptoms by 18% (odds ratio [OR] = 1.18, 95% confidence interval [CI], 0.99-1.40), the odds of a URI + cold symptoms + pulmonary eosinophilic inflammation by 31% (OR = 1.31, 95% CI, 1.10-1.57), and the odds of a URI + cold symptoms + reduced lung function by 45% (OR = 1.45, 95% CI, 1.13-1.85). Mouse allergen concentrations were positively associated with all outcomes. Associations were suggestively stronger among children sensitized to pest allergens.
conclusionsCockroach and mouse, but not dog or cat, allergen exposure may predispose children with asthma to URIs with colds and lower respiratory outcomes.
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