Observational studyThe Journal of pediatrics2024
Risk Assessment of Cognitive Impairment at 2 Years of Age in Infants Born Extremely Preterm Using the INTERGROWTH-21st Growth Standards.
Observational study in The Journal of pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00063063 (Generic Database), which is not on this map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Generic Database: A Survey of Morbidity and Mortality in Very Low Birth Weight Infants
Who cites it
9 citing papers in PubMed.
- Growth at 2 years in children born preterm: donor milk versus preterm formula.Pediatric research · 2026Trial
- Long-term growth and neurodevelopment of extremely preterm infants randomized to fortified human milk diets enriched with a protein supplement.Pediatric research · 2026Trial
- Time to regain birthweight and in-hospital outcomes among United States-born extremely preterm newborns.Pediatric research · 2026Trial
- Severity of Bronchopulmonary Dysplasia in Infants Born Extremely Preterm and Randomized to Early Human Milk Fortification with a Donor Milk-Derived Fortifier for 2 Weeks.The Journal of pediatrics · 2025Trial
- Effect of early antibiotic exposure on necrotizing enterocolitis and growth in extremely preterm infants.Pediatric research · 2025Trial
- Gut microbial differences and function in infants with gastroschisis: a pilot prospective cohort study.Beneficial microbes · 2026Article
- Fenton vs INTERGROWTH-21st charts in preterm infants < 32 weeks: impact of chart selection on growth classification.European journal of pediatrics · 2026Article
- Early parenteral lipid intake supports cerebellar neurometabolism at term-age in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2025Observational
- Exclusive enteral nutrition in preterm infants: How early is too early?Seminars in fetal & neonatal medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
objectiveTo assess the risk of cognitive impairment among infants born extremely preterm using the INTERGROWTH-21st standards. STUDY
designWe analyzed anthropometric data at birth and 36 weeks postmenstrual age (PMA) from infants born extremely preterm (24-26 weeks of gestation) admitted to US neonatal units between 2008 and 2018. To determine INTERGROWTH-21st z-score values that indicate an increased risk of cognitive impairment at 2 years of age (Bayley cognitive score <85), we employed classification and regression trees and redefined growth failure (weight, length, and head circumference z-scores at 36 weeks PMA) and growth faltering (weight, length, and head circumference z-score declines from birth to 36 weeks PMA).
resultsAmong 5393 infants with a mean gestational age of 25 weeks, growth failure defined as a weight z-score of -1.8 or below at 36 weeks PMA and growth faltering defined as a weight z-score decline of 1.1 or greater from birth to 36 weeks PMA indicated a higher likelihood of cognitive impairment. A length z-score less than -1 at 36 weeks PMA had the highest sensitivity to detect cognitive impairment at 2 years (80%). A head circumference z-score decline of 2.43 or greater from birth to 36 weeks PMA had the highest specificity (86%). Standard definitions had fair to low sensitivity and specificity for risk detection of cognitive impairment.
conclusionsLength and head circumference z-scores had the highest sensitivity and specificity for risk detection of cognitive impairment. Monitoring these growth parameters could guide earlier individualized interventions with potential to reduce cognitive impairment. CLINICAL
trial registrationClinicalTrials.gov ID Generic Database: NCT00063063.
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Registered trials
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