Evidence map›Paper›PMID 39168078›Full record

ArticleVaccine2024

Pneumococcal carriage and changes in serotype distribution post- PCV13 introduction in children in Matiari, Pakistan.

Izn Iqbal, Shahira Shahid, Samiah Kanwar, Furqan Kabir, Fayaz Umrani, Sheraz Ahmed, Waqasuddin Khan, Muhammad Farrukh Qazi, Fatima Aziz, Sahrish Muneer and 14 more

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Article in Vaccine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Izn IqbalDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Shahira ShahidDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Samiah KanwarDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Furqan KabirInfectious Diseases Research Laboratory (IDRL), Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Fayaz UmraniDepartment of Community Health Sciences, Aga Khan University, Karachi, Pakistan.
Sheraz AhmedDepartment of Community Health Sciences, Aga Khan University, Karachi, Pakistan.
Waqasuddin KhanDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Muhammad Farrukh QaziDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Fatima AzizInfectious Diseases Research Laboratory (IDRL), Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Sahrish MuneerInfectious Diseases Research Laboratory (IDRL), Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Adil KalamInfectious Diseases Research Laboratory (IDRL), Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Aneeta HotwaniInfectious Diseases Research Laboratory (IDRL), Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Junaid MehmoodDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Abdul Khalique QureshiDepartment of Community Health Sciences, Aga Khan University, Karachi, Pakistan.
Zahra HasanDepartment of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan.
Sadia ShakoorDepartment of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan.
Shaper MirzaSyed Babar Ali School of Science and Engineering, Lahore University of Management Sciences, Lahore, Pakistan.
Lesley McGeeDivision of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Stephanie W LoParasites and Microbes, Wellcome Sanger Institute, Hinxton, UK.
Narender KumarParasites and Microbes, Wellcome Sanger Institute, Hinxton, UK.
Iqbal AzamDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Stephen D BentleyParasites and Microbes, Wellcome Sanger Institute, Hinxton, UK.
Fyezah JehanDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Muhammad Imran NisarDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan. Electronic address: imran.nisar@aku.edu.

Funding

Gates Foundation INV-003570Wellcome Trust
6 · The paper itself

Abstract

backgroundIn early 2021, the 10-valent Pneumococcal conjugate vaccine (PCV10) was replaced with 13-valent (PCV13) by the federal directorate of immunization (FDI), Pakistan. We assessed the impact of a higher valent vaccine, PCV13, on the serotype distribution of nasopharyngeal carriage in rural Pakistan.

methodsChildren <2 years were randomly selected from two rural union councils of Matiari, Sindh in Pakistan between September-October,2022. Clinical, sociodemographic and vaccination histories were recorded. Nasopharyngeal swabs were collected and processed at Infectious Disease Research Laboratory, Aga Khan University, Karachi. Whole genome sequencing was performed on the culture positive isolates.

resultsOf the 200 children enrolled, pneumococcus was detected in 140(70 %) isolates. Majority of age-eligible children (60.1 %,110/183) received 3 PCV13 doses. PCV10 carriage declined from 13.2 %(78/590) in 2017/18 to 7.2 % (10/140) in 2022, additional PCV13 serotypes (3, 6A/6C and 19A) decreased from 18.5 %(109/590) to 11.4 %(16/140) while non-PCV13 serotypes increased from 68.3 %(403/590) to 81.4 %(114/140). There were 88.5 %(n = 124), 80.7 %(n = 113), 55.0 %(n = 77), and 46.0 %(n = 65) isolates predicted to be resistant to cotrimoxazole, penicillin(meningitis cut-off), tetracycline, and erythromycin respectively.

conclusionReplacing PCV10 with PCV13 rapidly decreased prevalence of PCV13 carriage among vaccinated children in Matiari, Pakistan. Vaccine-driven selection pressure may have been responsible for the increase of non-PCV13 serotypes.

Indexed as

Carrier StateNasopharynxPneumococcal InfectionsPneumococcal VaccinesSerogroupStreptococcus pneumoniaeAnti-Bacterial AgentsChild, PreschoolFemaleHumansInfantMalePakistanRural PopulationVaccines, ConjugateWhole Genome Sequencing10-valent pneumococcal conjugate vaccine13-valent pneumococcal vaccineAnti-Bacterial AgentsPneumococcal VaccinesVaccines, ConjugateBacterial genomicsGenomic epidemiologyPneumococcal carriagePneumococcal conjugate vaccineStreptococcus pneumoniae

Identifiers

PMID39168078
PMCPMC11413484

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