Evidence map›Paper›PMID 39167847›Full record

ArticleStem cell research2024

Generation of four distinct isogenic cell lines with truncating variants in I-band or A-band titin.

Hanne M Boen, Bert Vandendriessche, Jolien Schippers, Laura Rabaut, Aleksandra Nijak-Paeske, Peter Ponsaerts, Emeline M Van Craenenbroeck, Bart Loeys, Maaike Alaerts

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Article in Stem cell research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hanne M BoenUniversity of Antwerp and Antwerp University Hospital, GENCOR, Cardiovascular Research, Belgium; University of Antwerp, GENCOR, Center of Medical Genetics, Belgium. Electronic address: hanne.boen@uantwerpen.be.
Bert VandendriesscheUniversity of Antwerp, GENCOR, Center of Medical Genetics, Belgium.
Jolien SchippersUniversity of Antwerp, GENCOR, Center of Medical Genetics, Belgium.
Laura RabautUniversity of Antwerp, GENCOR, Center of Medical Genetics, Belgium.
Aleksandra Nijak-PaeskeUniversity of Antwerp, GENCOR, Center of Medical Genetics, Belgium.
Peter PonsaertsUniversity of Antwerp, Vaccine and Infectious Disease Institute, Belgium.
Emeline M Van CraenenbroeckUniversity of Antwerp and Antwerp University Hospital, GENCOR, Cardiovascular Research, Belgium.
Bart LoeysUniversity of Antwerp, GENCOR, Center of Medical Genetics, Belgium.
Maaike AlaertsUniversity of Antwerp, GENCOR, Center of Medical Genetics, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Truncating variants in TTN (TTNtv) are present in 15-25 % of patients with idiopathic dilated cardiomyopathy. Interestingly, the pathogenicity of TTNtv seems to be linked to their location within the gene. More proximal I-band TTNtv (TTNtvI) harbour less pathogenic potential than distant A-band TTNtv (TTNtvA). We created isogenic human induced pluripotent stem cell lines (hiPSC) with TTNtvI and TTNtvA using CRISPR/Cas9, for the investigation of the pathomechanism in hiPSC-derived cardiomyocytes (hiPSC-CMs). Exon 48 (E48), located in the I-band, and exon 357 (E357), located in the A-band were targeted.

Indexed as

ConnectinInduced Pluripotent Stem CellsCell LineCRISPR-Cas SystemsHumansMyocytes, CardiacConnectinTTN protein, human

Identifiers

PMID39167847
PMCPMC11649528

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.