Evidence map›Paper›PMID 39167750›Full record

ArticleNeurology2024

Baseline and Longitudinal MRI Markers Associated With 16-Year Mortality in Patients With Cerebral Small Vessel Disease.

Fang Yi, Mina A Jacob, Jamie I Verhoeven, Mengfei Cai, Marco Duering, Anil Man Tuladhar, Frank-Erik De Leeuw

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fang YiFrom the Department of Geriatrics (F.Y.), Xiangya Hospital, Central South University, China; Department of Neurology (M.A.J., J.I.V., A.M.T., F.-E.D.L.), Research Institute for Medical Innovation, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, the Netherlands; Department of Neurology (M.C.), Guangdong Neuroscience Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, China; and Department of Biomedical Engineering (M.D.), Medical Image Analysis Center (MIAC AG) and qbig, University of Basel, Switzerland.ORCID 0000-0003-3685-9047
Mina A JacobFrom the Department of Geriatrics (F.Y.), Xiangya Hospital, Central South University, China; Department of Neurology (M.A.J., J.I.V., A.M.T., F.-E.D.L.), Research Institute for Medical Innovation, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, the Netherlands; Department of Neurology (M.C.), Guangdong Neuroscience Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, China; and Department of Biomedical Engineering (M.D.), Medical Image Analysis Center (MIAC AG) and qbig, University of Basel, Switzerland.ORCID 0000-0002-3018-4109
Jamie I VerhoevenFrom the Department of Geriatrics (F.Y.), Xiangya Hospital, Central South University, China; Department of Neurology (M.A.J., J.I.V., A.M.T., F.-E.D.L.), Research Institute for Medical Innovation, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, the Netherlands; Department of Neurology (M.C.), Guangdong Neuroscience Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, China; and Department of Biomedical Engineering (M.D.), Medical Image Analysis Center (MIAC AG) and qbig, University of Basel, Switzerland.ORCID 0000-0002-1229-3715
Mengfei CaiFrom the Department of Geriatrics (F.Y.), Xiangya Hospital, Central South University, China; Department of Neurology (M.A.J., J.I.V., A.M.T., F.-E.D.L.), Research Institute for Medical Innovation, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, the Netherlands; Department of Neurology (M.C.), Guangdong Neuroscience Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, China; and Department of Biomedical Engineering (M.D.), Medical Image Analysis Center (MIAC AG) and qbig, University of Basel, Switzerland.ORCID 0000-0003-0927-2558
Marco DueringFrom the Department of Geriatrics (F.Y.), Xiangya Hospital, Central South University, China; Department of Neurology (M.A.J., J.I.V., A.M.T., F.-E.D.L.), Research Institute for Medical Innovation, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, the Netherlands; Department of Neurology (M.C.), Guangdong Neuroscience Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, China; and Department of Biomedical Engineering (M.D.), Medical Image Analysis Center (MIAC AG) and qbig, University of Basel, Switzerland.ORCID 0000-0003-2302-3136
Anil Man TuladharFrom the Department of Geriatrics (F.Y.), Xiangya Hospital, Central South University, China; Department of Neurology (M.A.J., J.I.V., A.M.T., F.-E.D.L.), Research Institute for Medical Innovation, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, the Netherlands; Department of Neurology (M.C.), Guangdong Neuroscience Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, China; and Department of Biomedical Engineering (M.D.), Medical Image Analysis Center (MIAC AG) and qbig, University of Basel, Switzerland.ORCID 0000-0002-4815-2834
Frank-Erik De LeeuwFrom the Department of Geriatrics (F.Y.), Xiangya Hospital, Central South University, China; Department of Neurology (M.A.J., J.I.V., A.M.T., F.-E.D.L.), Research Institute for Medical Innovation, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, the Netherlands; Department of Neurology (M.C.), Guangdong Neuroscience Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, China; and Department of Biomedical Engineering (M.D.), Medical Image Analysis Center (MIAC AG) and qbig, University of Basel, Switzerland.ORCID 0000-0003-2221-3026

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesInformation on whether small vessel disease (SVD) reduces life expectancy is limited. Moreover, the excess mortality risk attributed specifically to SVD compared with controls from the general population has not been evaluated. This study aimed to investigate the baseline and progression of MRI markers of SVD associated with mortality in a 16-year follow-up cohort study and to determine the excess long-term mortality risk of patients with SVD.

methodsParticipants with SVD from the Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Imaging Cohort (RUN DMC) study (with MRI assessments in 2006, 2011, 2015, and 2020) were followed until their death or December 1, 2021. Adjusted Cox regression analyses and linear mixed-effect regression models were used to investigate the association between MRI markers of SVD and mortality. The excess mortality risk of SVD was calculated by comparing mortality data of the RUN DMC study with the general population matched by sex, age, and calendar year.

results200 of 503 (39.9%) participants died during a follow-up period of 15.9 years. Cause of death was available for 182 (91%) participants. Baseline white matter hyperintensity volume (HR 1.3 per 1-SD increase [95% CI 1.1-1.5], DISCUSSION: Excess long-term mortality risk only exists in patients with severe SVD (Fazekas score of 3, presence of lacunes, or lower microstructural integrity). This could help in assisting clinicians to predict the clinical outcomes of patients with SVD by severity.

Indexed as

Cerebral Small Vessel DiseasesMagnetic Resonance ImagingAgedAged, 80 and overCohort StudiesDiffusion Tensor ImagingFemaleFollow-Up StudiesHumansLongitudinal StudiesMaleMiddle AgedWhite Matter

Identifiers

PMID39167750
PMCPMC11379354

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.