Evidence map›Paper›PMID 39167748›Full record

Trial reportNeurology2024

Migraine and Risk of Parkinson Disease in Women: A Cohort Study.

Ricarda S Schulz, Toivo Glatz, Julie E Buring, Pamela M Rist, Tobias Kurth

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00000479 (Women's Health Study of Low-dose Aspirin and Vitamin E in Apparently Healthy Women), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00000479 phase3completednot on this map

Women's Health Study of Low-dose Aspirin and Vitamin E in Apparently Healthy Women

TypeinterventionalSponsorBrigham and Women's HospitalRan1992 to 2005Enrolled39,876ConditionsCardiovascular Diseases, Cerebrovascular Disorders, Coronary Disease, Heart DiseasesArmsAspirin, Vitamin E, Placebo
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ricarda S SchulzFrom the Charité - Universitätsmedizin Berlin (R.S.S., T.G., T.K.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Public Health, Germany; and Division of Preventive Medicine (J.E.B., P.M.R., T.K.), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.ORCID 0009-0006-9725-7620
Toivo GlatzFrom the Charité - Universitätsmedizin Berlin (R.S.S., T.G., T.K.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Public Health, Germany; and Division of Preventive Medicine (J.E.B., P.M.R., T.K.), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0002-8994-7860
Julie E BuringFrom the Charité - Universitätsmedizin Berlin (R.S.S., T.G., T.K.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Public Health, Germany; and Division of Preventive Medicine (J.E.B., P.M.R., T.K.), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Pamela M RistFrom the Charité - Universitätsmedizin Berlin (R.S.S., T.G., T.K.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Public Health, Germany; and Division of Preventive Medicine (J.E.B., P.M.R., T.K.), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0003-3543-045X
Tobias KurthFrom the Charité - Universitätsmedizin Berlin (R.S.S., T.G., T.K.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Public Health, Germany; and Division of Preventive Medicine (J.E.B., P.M.R., T.K.), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0001-7169-2620

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesMigraine and Parkinson disease (PD) are common neurologic disorders, which are hypothesized to share some pathophysiologic mechanisms. However, data on the association between migraine and risk of developing PD are sparse. We estimate the effect of migraine, migraine subtypes, and migraine episode frequency on the risk of developing PD in middle-aged and older women.

methodsWe used data from the Women's Health Study, a United States-based cohort of women in health professions aged 45 years and older at baseline (1992-1995). Only women with complete self-reported information on migraine and headache and no history of PD were included. Participants were followed up for self-reported physician-diagnosed PD through December 31, 2021. We used multivariable Cox proportional hazards models to estimate hazard ratios (HRs) and corresponding 95% CIs of the association between migraine, migraine subtypes, and migraine episode frequency and the risk of developing PD.

resultsA total of 39,312 women were included in the analyses. Among those, 7,321 women (18.6%) reported any migraine at baseline, of whom 2,153 (5.5%) reported a history of migraine, 2,057 (5.2%) reported migraine with aura, and 3,111 (7.9%) reported migraine without aura. During a mean follow-up of 22.0 years, 685 PD cases were reported. Of those, 128 (18.7%) were reported by women who also reported any migraine and 557 (81.3%) by women without any migraine. After adjusting for confounding, the HR for the association of any migraine on the risk of PD was 1.07 (0.88-1.29). Compared with women without migraine, the HRs (95% CI) for PD were 0.87 (0.59-1.27) for migraine with aura, 1.21 (0.93-1.58) for migraine without aura, and 1.05 (0.76-1.45) for history of migraine. Compared with those with a migraine frequency of less than monthly, the HRs were 1.09 (0.64-1.87) for a monthly frequency and 1.10 (0.44-2.75) for a weekly or greater frequency. DISCUSSION: In this large cohort of women, the risk of developing PD was not elevated among those experiencing migraine, irrespective of migraine subtypes or the frequency of migraine. The generalizability of our findings to other populations, such as men, should be further investigated. TRIAL REGISTRATION INFORMATION: ClinicalTrials.gov Identifier: NCT00000479.

Indexed as

Migraine DisordersParkinson DiseaseAgedCohort StudiesFemaleHumansMiddle AgedRisk FactorsUnited States

Identifiers

PMID39167748
PMCPMC11338499

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.