Evidence map›Paper›PMID 39167662›Full record

ArticleScience translational medicine2024

Intestinal helminth infection impairs vaccine-induced T cell responses and protection against SARS-CoV-2 in mice.

Pritesh Desai, Courtney E Karl, Baoling Ying, Chieh-Yu Liang, Tamara Garcia-Salum, Ana Carolina Santana, Felipe Ten-Caten, Joseph F Urban, Sayda M Elbashir, Darin K Edwards and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Science translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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  6. Review
  7. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Pritesh DesaiDepartment of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-4697-9475
Courtney E KarlDepartment of Molecular Microbiology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-9950-2155
Baoling YingDepartment of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-9344-9004
Chieh-Yu LiangDepartment of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-4624-7212
Tamara Garcia-SalumEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30317, USA.ORCID 0000-0002-0170-9965
Ana Carolina SantanaEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30317, USA.
Felipe Ten-CatenEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30317, USA.ORCID 0000-0001-7771-1490
Joseph F UrbanUS Department of Agriculture, Agricultural Research Services, Beltsville Human Nutrition Research Center, Diet, Genomics, and Immunology Laboratory, and Beltsville Agricultural Research Center, Animal Parasitic Diseases Laboratory, Beltsville, MD 20705, USA.ORCID 0000-0002-1590-8869
Sayda M ElbashirModerna Inc., Cambridge, MA 02142, USA.ORCID 0000-0001-6250-9679
Darin K EdwardsModerna Inc., Cambridge, MA 02142, USA.
Susan P RibeiroEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30317, USA.ORCID 0000-0002-3127-3138
Larissa B ThackrayDepartment of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-9380-6569
Rafick P SekalyEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30317, USA.ORCID 0000-0002-7816-4828
Michael S DiamondDepartment of Medicine, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-8791-3165

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although vaccines have reduced the burden of COVID-19, their efficacy in helminth infection-endemic areas is not well characterized. We evaluated the impact of infection by

Indexed as

CD8-Positive T-LymphocytesCOVID-19COVID-19 VaccinesInterleukin-10Nematospiroides dubiusSARS-CoV-2AnimalsFemaleMiceMice, Inbred C57BLSpike Glycoprotein, CoronavirusSTAT6 Transcription FactorStrongylida InfectionsT-LymphocytesCOVID-19 VaccinesInterleukin-10Spike Glycoprotein, Coronavirusspike protein, SARS-CoV-2STAT6 Transcription Factor

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.