Evidence map›Paper›PMID 39167532›Full record

ArticleJournal of palliative medicine2025

Top Ten Tips Palliative Care Clinicians Should Know About Designing a Clinical Trial in Palliative Care.

Taylan Gurgenci, Cian O'Leary, Jennifer Philip, Eduardo Bruera, Mellar Davis, Meera R Agar, David Hui, Camilla Zimmermann, Sriram Yennu, Janet Hardy and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of palliative medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Taylan GurgenciDepartment of Palliative and Supportive Care, Brisbane, Queensland, Australia.
Cian O'LearyCancer Services, Mater Health, Brisbane, Queensland, Australia.
Jennifer PhilipDepartment of Palliative Care, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.ORCID 0000-0002-3312-0645
Eduardo BrueraDepartment of Palliative, Rehabilitation, & Integrative Medicine, The University of Texas MD Anderson Cancer, Houston, Texas, USA.
Mellar DavisDirector of Palliative Care Research at Geisinger Medical Center, Geisinger Commonwealth School of Medicine, Scranton PA, Danville, Pennsylvania, USA.
Meera R AgarFaculty of Health,IMPACCT, University of Technology Sydney, Sydney, New South Wales, Australia.
David HuiDepartment of Palliative, Rehabilitation, & Integrative Medicine, The University of Texas MD Anderson Cancer, Houston, Texas, USA.
Camilla ZimmermannDepartment of Supportive Care, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.ORCID 0000-0003-4889-0244
Sriram YennuDepartment of Palliative, Rehabilitation, & Integrative Medicine, The University of Texas MD Anderson Cancer, Houston, Texas, USA.
Janet HardyCancer Program, Mater Research Institute-University of Queensland, Brisbane, Queensland, Australia.
Sebastiano MercadantePain Relief and Supportive-Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy.ORCID 0000-0001-9859-6487
William E RosaDepartment of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID 0000-0002-0680-8911
Phillip GoodDepartment of Palliative and Supportive Care, Brisbane, Queensland, Australia.ORCID 0000-0002-8198-0375

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

The palliative care field is experiencing substantive growth in clinical trial-based research. Randomized controlled trials provide the necessary rigor and conditions for assessing a treatment's efficacy in a controlled population. It is therefore important that a trial is meticulously designed from the outset to ensure the integrity of the ultimate results. In this article, our team discusses ten tips on clinical trial design drawn from collective experiences in the field. These ten tips cover a range of topics that can prove challenging in trial design, from developing initial methodologies to planning sample size and powering the trial, as well as collaboratively navigating the ethical issues of trial initiation and implementation as a cohesive team. We aim to help new researchers design sound trials and continue to grow the evidence base for our specialty. The guidance provided here can be used independently or in addition to the ten tips provided by this team in a separate article focused on what palliative care clinicians should know about interpreting a clinical trial.

Indexed as

Clinical Trials as TopicPalliative CareRandomized Controlled Trials as TopicResearch DesignHumanscriteriadesigning a clinical trialdiverse methodologiespalliative carepilot studyvalid outcomes

Identifiers

PMID39167532
PMCPMC12340496

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.