ArticleCell reports2024
Heterogeneous orientation tuning in the primary visual cortex of mice diverges from Gabor-like receptive fields in primates.
Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Laminar-specific control of response gain and orientation-tuning by parvalbumin-expressing inhibitory interneurons in primate visual cortex.Research square · 2026Article
- Feature-specific inhibitory connectivity augments the accuracy of cortical representations.bioRxiv : the preprint server for biology · 2025Article
- Brain-like variational inference.ArXiv · 2025Article
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13 authors.
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Abstract
A key feature of neurons in the primary visual cortex (V1) of primates is their orientation selectivity. Recent studies using deep neural network models showed that the most exciting input (MEI) for mouse V1 neurons exhibit complex spatial structures that predict non-uniform orientation selectivity across the receptive field (RF), in contrast to the classical Gabor filter model. Using local patches of drifting gratings, we identified heterogeneous orientation tuning in mouse V1 that varied up to 90° across sub-regions of the RF. This heterogeneity correlated with deviations from optimal Gabor filters and was consistent across cortical layers and recording modalities (calcium vs. spikes). In contrast, model-synthesized MEIs for macaque V1 neurons were predominantly Gabor like, consistent with previous studies. These findings suggest that complex spatial feature selectivity emerges earlier in the visual pathway in mice than in primates. This may provide a faster, though less general, method of extracting task-relevant information.
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