Evidence map›Paper›PMID 39167471›Full record

ArticleSocial cognitive and affective neuroscience2024

Impact of NPSR1 gene variation on the neural correlates of phasic and sustained fear in spider phobia-an imaging genetics and independent replication approach.

Elisabeth J Leehr, Leonie S Brede, Joscha Böhnlein, Kati Roesmann, Bettina Gathmann, Martin J Herrmann, Markus Junghöfer, Hanna Schwarzmeier, Fabian R Seeger, Niklas Siminski and 7 more

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Article in Social cognitive and affective neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

17 authors.

Elisabeth J LeehrInstitute for Translational Psychiatry, University of Münster, Münster 48149, Germany.ORCID 0000-0002-9264-5003
Leonie S BredeInstitute for Translational Psychiatry, University of Münster, Münster 48149, Germany.
Joscha BöhnleinInstitute for Translational Psychiatry, University of Münster, Münster 48149, Germany.
Kati RoesmannInstitute for Clinical Psychology, University of Siegen, Siegen 57072, Germany.
Bettina GathmannInstitute of Medical Psychology and Systems Neuroscience, University of Münster, Münster 48149, Germany.
Martin J HerrmannDepartment of Psychiatry, Psychosomatics, and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Wurzburg 97080, Germany.
Markus JunghöferInstitute for Biomagnetism and Biosignalanalysis, University of Münster, Münster 48149, Germany.
Hanna SchwarzmeierDepartment of Psychiatry, Psychosomatics, and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Wurzburg 97080, Germany.
Fabian R SeegerDepartment of Psychiatry, Psychosomatics, and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Wurzburg 97080, Germany.
Niklas SiminskiDepartment of Psychiatry, Psychosomatics, and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Wurzburg 97080, Germany.
Thomas StraubeInstitute of Medical Psychology and Systems Neuroscience, University of Münster, Münster 48149, Germany.
Anna Luisa KlahnDepartment of Psychiatry and Neurochemistry, University of Gothenburg, Gothenburg 41345, Sweden.
Heike WeberDepartment of Psychiatry, Psychosomatics, and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Wurzburg 97080, Germany.
Miriam A SchieleDepartment of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg 79104, Germany.
Katharina DomschkeDepartment of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg 79104, Germany.
Ulrike LuekenDepartment of Psychiatry, Psychosomatics, and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Wurzburg 97080, Germany.
Udo DannlowskiInstitute for Translational Psychiatry, University of Münster, Münster 48149, Germany.

Funding

Deutsche Forschungsgemeinschaft 44541416-TRR 58"Innovative Medizinische Forschung" (IMF) of the Medical Faculty, University of Münster LE121703 and LE121904Interdisciplinary Center for Clinical Research (IZKF) of the medical faculty of Münster Dan3/012/17
6 · The paper itself

Abstract

The functional neuropeptide S receptor 1 (NPSR1) gene A/T variant (rs324981) is associated with fear processing. We investigated the impact of NPSR1 genotype on fear processing and on symptom reduction following treatment in individuals with spider phobia. A replication approach was applied [discovery sample: Münster (MS) nMS = 104; replication sample Würzburg (WZ) nWZ = 81]. Participants were genotyped for NPSR1 rs324981 [T-allele carriers (risk) versus AA homozygotes (no-risk)]. A sustained and phasic fear paradigm was applied during functional magnetic resonance imaging. A one-session virtual reality exposure treatment was conducted. Change of symptom severity from pre to post treatment and within session fear reduction were assessed. T-allele carriers in the discovery sample displayed lower anterior cingulate cortex (ACC) activation compared to AA homozygotes independent of condition. For sustained fear, this effect was replicated within a small cluster and medium effect size. No association with symptom reduction was found. Within-session fear reduction was negatively associated with ACC activation in T-allele carriers in the discovery sample. NPSR1 rs324981 genotype might be associated with fear processing in the ACC in spider phobia. Interpretation as potential risk-increasing function of the NPSR1 rs324981 T-allele via impaired top-down control of limbic structures remains speculative. Potential association with symptom reduction warrants further research.

Indexed as

FearMagnetic Resonance ImagingPhobic DisordersReceptors, G-Protein-CoupledAdultAnimalsBrainFemaleGenotypeGyrus CinguliHumansMaleMiddle AgedPolymorphism, Single NucleotideSpidersYoung AdultNPSR1 protein, humanReceptors, G-Protein-Coupledimaging geneticsNPSR1phasic fearsustained fear

Identifiers

PMID39167471
PMCPMC11412251

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.