ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2025
How we measure hypoglossal nerve stimulator outcome matters: titration vs single amplitude efficacy sleep studies.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Therapeutic options for patients with obstructive sleep apnoea: a retrospective review of difficult-to-treat cases in a multidisciplinary approach.BMJ open respiratory research · 2026Article
- The Association of Upper Airway Anatomy and Hypoglossal Nerve Stimulation Response in OSA.The Laryngoscope · 2026Article
- Hypoglossal Nerve Stimulation for Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis on Responder-Based Outcomes and Between-Study Heterogeneity.Journal of clinical medicine · 2026Review
- Impact of Bariatric Surgery on Hypoglossal Nerve Stimulation Outcomes.The Laryngoscope · 2026Article
- Differential association of body mass index with hypoglossal nerve stimulation efficacy by pharyngeal collapse pattern in obstructive sleep apnea.medRxiv : the preprint server for health sciences · 2026Article
- Recent Advancements in the Clinical Pathway of Respiration-Synchronized Hypoglossal Nerve Stimulation Therapy for Obstructive Sleep Apnea.Journal of clinical medicine · 2025Review
- Impact of Nasal Pathology on Efficacy of Hypoglossal Nerve Stimulation for Obstructive Sleep Apnea.The Laryngoscope · 2025Article
- Adherence to unilateral hypoglossal nerve stimulation and changes in Epworth Sleepiness Scale scores.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
- Classifying the types of therapeutic sleep studies.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
- Backscattered Ultrasonographic Imaging of the Tongue and Outcome in Hypoglossal Nerve Stimulation.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025Article
- Measuring hypoglossal nerve stimulator outcomes.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesHypoglossal nerve stimulator (HGNS) is a common treatment for obstructive sleep apnea. Objective assessment of HGNS efficacy measures apnea-hypopnea index (AHI) by multiamplitude titration polysomnography (tPSG) and/or a single amplitude, full-night type 3 home sleep study (eHST). Both tests have been used to determine efficacy despite significantly different protocols. This project's aim was to determine differences in objective outcomes in HGNS patients who underwent both tPSG and eHST postoperatively.
methodsData from 379 consecutive HGNS patients were retrospectively reviewed. Inclusion requirements were a preoperative sleep study, a postoperative tPSG, and then an eHST, which at our institution is a type 3 home study. AHI mean and differences were calculated. Wilcoxon rank sum tests were used to analyze differences between tPSG and eHST. Sher
resultsUltimately 61 patients met inclusion criteria with an average preoperative AHI = 33.2 events/h. When comparing the patient's tPSG vs eHST, tPSG AHI was significantly lower (AHI = 8.8 events/h vs AHI = 17.6 events/h; respectively,
conclusionsHGNS patient's postoperative tPSG AHI was significantly lower than their eHST outcome. This work highlights the importance of reporting the type of postoperative study used in evaluating HGNS efficacy and the need for single amplitude, full-night studies to assess HGNS efficacy more accurately. CITATION: Kaffenberger TM, Sina EM, Hambach B, et al. How we measure hypoglossal nerve stimulator outcome matters: titration vs single amplitude efficacy sleep studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.