Evidence map›Paper›PMID 39167325›Full record

ReviewClinical rheumatology2024

Application of methylation in the diagnosis of ankylosing spondylitis.

Xiang Ding, Jian Liu, Xiaolu Chen, Xianheng Zhang, Yanyan Fang, Dan Huang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Clinical rheumatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiang DingAnhui University of Traditional Chinese Medicine, Hefei, 230031, Anhui, China.
Jian LiuDepartment of Rheumatology and Immunology, First Affiliated Hospital of Anhui, University of Traditional Chinese Medicine, Shushan, Hefei, 230038, Anhui, China. liujianahzy@126.com.ORCID http://orcid.org/0000-0003-3101-7553
Xiaolu ChenAnhui University of Traditional Chinese Medicine, Hefei, 230031, Anhui, China.
Xianheng ZhangAnhui University of Traditional Chinese Medicine, Hefei, 230031, Anhui, China.
Yanyan FangAnhui University of Traditional Chinese Medicine, Hefei, 230031, Anhui, China.
Dan HuangAnhui University of Traditional Chinese Medicine, Hefei, 230031, Anhui, China.

Funding

Pharm-Bio Technology and Traditional Medicine Centre, Mbarara University of Science and Technology zyyzdxk-2023100the 2021 Open Fund of Anhui Provincial Key Laboratory of Applied Basic and Development Research in Modern Traditional Chinese Medicine 2021AKLMCM002the National Natural Science Foundation of China 82205054
6 · The paper itself

Abstract

Ankylosing spondylitis (AS) is a chronic inflammatory autoimmune disease, mainly characterized by perifibrocartilage osteitis of the sacroiliac joints and spinal enthesitis. To date, the exact pathogenesis of AS remains elusive. It is generally believed that AS is a multifactorial disease involving genetics, infection, environment, and immunity. Among them, genetic factors are the primary determinants of disease risk and severity. In recent years, epigenetic mechanisms such as DNA methylation have been extensively surveyed with respect to the pathogenesis of AS. This review summarizes the latest research progress of methylation in AS, from whole-genome sequencing to individual differentially methylated gene. And finally, the role of methylase in AS inflammation, autophagy, and osteogenic differentiation was explored. In summary, the results of this review attempt to explain the role of methylation in the occurrence and development of AS and point out the shortcomings of current methylation research, providing directions for subsequent methylation research in AS.

Indexed as

DNA MethylationEpigenesis, GeneticSpondylitis, AnkylosingHumansAnkylosing spondylitisBiological processCPG islandEpigeneticsMethylation

Identifiers

PMID39167325

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.