ArticleRadiology. Artificial intelligence2024
nnU-Net-based Segmentation of Tumor Subcompartments in Pediatric Medulloblastoma Using Multiparametric MRI: A Multi-institutional Study.
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Article in Radiology. Artificial intelligence, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed.
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- Towards human-centric intelligent treatment planning for radiation therapy.NPJ digital medicine · 2026Review
- From Lesion to Decision: AI for ARIA Detection and Predictive Imaging in Alzheimer's Disease.Biomedicines · 2025Review
- A Multidimensional Particle Swarm Optimization-Based Algorithm for Brain MRI Tumor Segmentation.Sensors (Basel, Switzerland) · 2025Article
- Habitat imaging with intratumoral radiomics for prediction of axillary response after neoadjuvant chemotherapy in breast cancer patients.Frontiers in molecular biosciences · 2025Article
- Advancing Pediatric Neuro-Oncology: Multi-institutional nnU-Net Segmentation of Medulloblastoma.Radiology. Artificial intelligence · 2024Article
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15 authors.
Rohan BarejaFrom the Department of Radiology, University of Wisconsin-Madison, Madison, Wis (R.B., M.I., I.Y.); University Hospitals, Cleveland, Ohio (D.M., A.N.); Departments of Biomedical Engineering (M.L., S.G., S.I.) and Neurosciences (P.D.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, Children's Hospital Los Angeles, Los Angeles, Calif (B.T.); Division of Hematology, Oncology & Bone Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio (R.S.); Department of Pediatrics, Keck School of Medicine of University of Southern California, Children's Hospital Los Angeles, Los Angeles, Calif (A.M.); Department of Pathology, Children's Hospital Los Angeles, Los Angeles, Calif (A.J.); Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (P.d.B.); William S. Middleton Memorial Veterans Affairs (VA) Healthcare, Madison, Wis (P.T.); and Department of Radiology and Biomedical Engineering, University of Wisconsin-Madison, 750 Highland Ave, Madison, WI 53726 (P.T.).ORCID 0000-0002-0635-7743
Marwa IsmailFrom the Department of Radiology, University of Wisconsin-Madison, Madison, Wis (R.B., M.I., I.Y.); University Hospitals, Cleveland, Ohio (D.M., A.N.); Departments of Biomedical Engineering (M.L., S.G., S.I.) and Neurosciences (P.D.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, Children's Hospital Los Angeles, Los Angeles, Calif (B.T.); Division of Hematology, Oncology & Bone Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio (R.S.); Department of Pediatrics, Keck School of Medicine of University of Southern California, Children's Hospital Los Angeles, Los Angeles, Calif (A.M.); Department of Pathology, Children's Hospital Los Angeles, Los Angeles, Calif (A.J.); Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (P.d.B.); William S. Middleton Memorial Veterans Affairs (VA) Healthcare, Madison, Wis (P.T.); and Department of Radiology and Biomedical Engineering, University of Wisconsin-Madison, 750 Highland Ave, Madison, WI 53726 (P.T.).ORCID 0000-0002-1396-0372
Douglas MartinFrom the Department of Radiology, University of Wisconsin-Madison, Madison, Wis (R.B., M.I., I.Y.); University Hospitals, Cleveland, Ohio (D.M., A.N.); Departments of Biomedical Engineering (M.L., S.G., S.I.) and Neurosciences (P.D.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, Children's Hospital Los Angeles, Los Angeles, Calif (B.T.); Division of Hematology, Oncology & Bone Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio (R.S.); Department of Pediatrics, Keck School of Medicine of University of Southern California, Children's Hospital Los Angeles, Los Angeles, Calif (A.M.); Department of Pathology, Children's Hospital Los Angeles, Los Angeles, Calif (A.J.); Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (P.d.B.); William S. Middleton Memorial Veterans Affairs (VA) Healthcare, Madison, Wis (P.T.); and Department of Radiology and Biomedical Engineering, University of Wisconsin-Madison, 750 Highland Ave, Madison, WI 53726 (P.T.).ORCID 0000-0003-4266-238X
Ameya NayateFrom the Department of Radiology, University of Wisconsin-Madison, Madison, Wis (R.B., M.I., I.Y.); University Hospitals, Cleveland, Ohio (D.M., A.N.); Departments of Biomedical Engineering (M.L., S.G., S.I.) and Neurosciences (P.D.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, Children's Hospital Los Angeles, Los Angeles, Calif (B.T.); Division of Hematology, Oncology & Bone Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio (R.S.); Department of Pediatrics, Keck School of Medicine of University of Southern California, Children's Hospital Los Angeles, Los Angeles, Calif (A.M.); Department of Pathology, Children's Hospital Los Angeles, Los Angeles, Calif (A.J.); Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (P.d.B.); William S. Middleton Memorial Veterans Affairs (VA) Healthcare, Madison, Wis (P.T.); and Department of Radiology and Biomedical Engineering, University of Wisconsin-Madison, 750 Highland Ave, Madison, WI 53726 (P.T.).ORCID 0000-0001-6846-2074
Ipsa YadavFrom the Department of Radiology, University of Wisconsin-Madison, Madison, Wis (R.B., M.I., I.Y.); University Hospitals, Cleveland, Ohio (D.M., A.N.); Departments of Biomedical Engineering (M.L., S.G., S.I.) and Neurosciences (P.D.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, Children's Hospital Los Angeles, Los Angeles, Calif (B.T.); Division of Hematology, Oncology & Bone Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio (R.S.); Department of Pediatrics, Keck School of Medicine of University of Southern California, Children's Hospital Los Angeles, Los Angeles, Calif (A.M.); Department of Pathology, Children's Hospital Los Angeles, Los Angeles, Calif (A.J.); Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (P.d.B.); William S. Middleton Memorial Veterans Affairs (VA) Healthcare, Madison, Wis (P.T.); and Department of Radiology and Biomedical Engineering, University of Wisconsin-Madison, 750 Highland Ave, Madison, WI 53726 (P.T.).ORCID 0000-0001-5414-7188
Murad LabbadFrom the Department of Radiology, University of Wisconsin-Madison, Madison, Wis (R.B., M.I., I.Y.); University Hospitals, Cleveland, Ohio (D.M., A.N.); Departments of Biomedical Engineering (M.L., S.G., S.I.) and Neurosciences (P.D.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, Children's Hospital Los Angeles, Los Angeles, Calif (B.T.); Division of Hematology, Oncology & Bone Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio (R.S.); Department of Pediatrics, Keck School of Medicine of University of Southern California, Children's Hospital Los Angeles, Los Angeles, Calif (A.M.); Department of Pathology, Children's Hospital Los Angeles, Los Angeles, Calif (A.J.); Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (P.d.B.); William S. Middleton Memorial Veterans Affairs (VA) Healthcare, Madison, Wis (P.T.); and Department of Radiology and Biomedical Engineering, University of Wisconsin-Madison, 750 Highland Ave, Madison, WI 53726 (P.T.).ORCID 0009-0006-9403-2266
Prateek DullurFrom the Department of Radiology, University of Wisconsin-Madison, Madison, Wis (R.B., M.I., I.Y.); University Hospitals, Cleveland, Ohio (D.M., A.N.); Departments of Biomedical Engineering (M.L., S.G., S.I.) and Neurosciences (P.D.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, Children's Hospital Los Angeles, Los Angeles, Calif (B.T.); Division of Hematology, Oncology & Bone Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio (R.S.); Department of Pediatrics, Keck School of Medicine of University of Southern California, Children's Hospital Los Angeles, Los Angeles, Calif (A.M.); Department of Pathology, Children's Hospital Los Angeles, Los Angeles, Calif (A.J.); Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (P.d.B.); William S. Middleton Memorial Veterans Affairs (VA) Healthcare, Madison, Wis (P.T.); and Department of Radiology and Biomedical Engineering, University of Wisconsin-Madison, 750 Highland Ave, Madison, WI 53726 (P.T.).ORCID 0009-0005-2094-4038
Sanya GargFrom the Department of Radiology, University of Wisconsin-Madison, Madison, Wis (R.B., M.I., I.Y.); University Hospitals, Cleveland, Ohio (D.M., A.N.); Departments of Biomedical Engineering (M.L., S.G., S.I.) and Neurosciences (P.D.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, Children's Hospital Los Angeles, Los Angeles, Calif (B.T.); Division of Hematology, Oncology & Bone Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio (R.S.); Department of Pediatrics, Keck School of Medicine of University of Southern California, Children's Hospital Los Angeles, Los Angeles, Calif (A.M.); Department of Pathology, Children's Hospital Los Angeles, Los Angeles, Calif (A.J.); Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (P.d.B.); William S. Middleton Memorial Veterans Affairs (VA) Healthcare, Madison, Wis (P.T.); and Department of Radiology and Biomedical Engineering, University of Wisconsin-Madison, 750 Highland Ave, Madison, WI 53726 (P.T.).
Benita TamraziFrom the Department of Radiology, University of Wisconsin-Madison, Madison, Wis (R.B., M.I., I.Y.); University Hospitals, Cleveland, Ohio (D.M., A.N.); Departments of Biomedical Engineering (M.L., S.G., S.I.) and Neurosciences (P.D.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, Children's Hospital Los Angeles, Los Angeles, Calif (B.T.); Division of Hematology, Oncology & Bone Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio (R.S.); Department of Pediatrics, Keck School of Medicine of University of Southern California, Children's Hospital Los Angeles, Los Angeles, Calif (A.M.); Department of Pathology, Children's Hospital Los Angeles, Los Angeles, Calif (A.J.); Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (P.d.B.); William S. Middleton Memorial Veterans Affairs (VA) Healthcare, Madison, Wis (P.T.); and Department of Radiology and Biomedical Engineering, University of Wisconsin-Madison, 750 Highland Ave, Madison, WI 53726 (P.T.).ORCID 0000-0003-4795-8454
Ralph SalloumFrom the Department of Radiology, University of Wisconsin-Madison, Madison, Wis (R.B., M.I., I.Y.); University Hospitals, Cleveland, Ohio (D.M., A.N.); Departments of Biomedical Engineering (M.L., S.G., S.I.) and Neurosciences (P.D.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, Children's Hospital Los Angeles, Los Angeles, Calif (B.T.); Division of Hematology, Oncology & Bone Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio (R.S.); Department of Pediatrics, Keck School of Medicine of University of Southern California, Children's Hospital Los Angeles, Los Angeles, Calif (A.M.); Department of Pathology, Children's Hospital Los Angeles, Los Angeles, Calif (A.J.); Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (P.d.B.); William S. Middleton Memorial Veterans Affairs (VA) Healthcare, Madison, Wis (P.T.); and Department of Radiology and Biomedical Engineering, University of Wisconsin-Madison, 750 Highland Ave, Madison, WI 53726 (P.T.).
Ashley MargolFrom the Department of Radiology, University of Wisconsin-Madison, Madison, Wis (R.B., M.I., I.Y.); University Hospitals, Cleveland, Ohio (D.M., A.N.); Departments of Biomedical Engineering (M.L., S.G., S.I.) and Neurosciences (P.D.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, Children's Hospital Los Angeles, Los Angeles, Calif (B.T.); Division of Hematology, Oncology & Bone Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio (R.S.); Department of Pediatrics, Keck School of Medicine of University of Southern California, Children's Hospital Los Angeles, Los Angeles, Calif (A.M.); Department of Pathology, Children's Hospital Los Angeles, Los Angeles, Calif (A.J.); Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (P.d.B.); William S. Middleton Memorial Veterans Affairs (VA) Healthcare, Madison, Wis (P.T.); and Department of Radiology and Biomedical Engineering, University of Wisconsin-Madison, 750 Highland Ave, Madison, WI 53726 (P.T.).ORCID 0000-0002-3038-8005
Alexander JudkinsFrom the Department of Radiology, University of Wisconsin-Madison, Madison, Wis (R.B., M.I., I.Y.); University Hospitals, Cleveland, Ohio (D.M., A.N.); Departments of Biomedical Engineering (M.L., S.G., S.I.) and Neurosciences (P.D.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, Children's Hospital Los Angeles, Los Angeles, Calif (B.T.); Division of Hematology, Oncology & Bone Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio (R.S.); Department of Pediatrics, Keck School of Medicine of University of Southern California, Children's Hospital Los Angeles, Los Angeles, Calif (A.M.); Department of Pathology, Children's Hospital Los Angeles, Los Angeles, Calif (A.J.); Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (P.d.B.); William S. Middleton Memorial Veterans Affairs (VA) Healthcare, Madison, Wis (P.T.); and Department of Radiology and Biomedical Engineering, University of Wisconsin-Madison, 750 Highland Ave, Madison, WI 53726 (P.T.).
Sukanya IyerFrom the Department of Radiology, University of Wisconsin-Madison, Madison, Wis (R.B., M.I., I.Y.); University Hospitals, Cleveland, Ohio (D.M., A.N.); Departments of Biomedical Engineering (M.L., S.G., S.I.) and Neurosciences (P.D.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, Children's Hospital Los Angeles, Los Angeles, Calif (B.T.); Division of Hematology, Oncology & Bone Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio (R.S.); Department of Pediatrics, Keck School of Medicine of University of Southern California, Children's Hospital Los Angeles, Los Angeles, Calif (A.M.); Department of Pathology, Children's Hospital Los Angeles, Los Angeles, Calif (A.J.); Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (P.d.B.); William S. Middleton Memorial Veterans Affairs (VA) Healthcare, Madison, Wis (P.T.); and Department of Radiology and Biomedical Engineering, University of Wisconsin-Madison, 750 Highland Ave, Madison, WI 53726 (P.T.).
Peter de BlankFrom the Department of Radiology, University of Wisconsin-Madison, Madison, Wis (R.B., M.I., I.Y.); University Hospitals, Cleveland, Ohio (D.M., A.N.); Departments of Biomedical Engineering (M.L., S.G., S.I.) and Neurosciences (P.D.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, Children's Hospital Los Angeles, Los Angeles, Calif (B.T.); Division of Hematology, Oncology & Bone Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio (R.S.); Department of Pediatrics, Keck School of Medicine of University of Southern California, Children's Hospital Los Angeles, Los Angeles, Calif (A.M.); Department of Pathology, Children's Hospital Los Angeles, Los Angeles, Calif (A.J.); Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (P.d.B.); William S. Middleton Memorial Veterans Affairs (VA) Healthcare, Madison, Wis (P.T.); and Department of Radiology and Biomedical Engineering, University of Wisconsin-Madison, 750 Highland Ave, Madison, WI 53726 (P.T.).ORCID 0000-0001-6623-3040
Pallavi TiwariFrom the Department of Radiology, University of Wisconsin-Madison, Madison, Wis (R.B., M.I., I.Y.); University Hospitals, Cleveland, Ohio (D.M., A.N.); Departments of Biomedical Engineering (M.L., S.G., S.I.) and Neurosciences (P.D.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, Children's Hospital Los Angeles, Los Angeles, Calif (B.T.); Division of Hematology, Oncology & Bone Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio (R.S.); Department of Pediatrics, Keck School of Medicine of University of Southern California, Children's Hospital Los Angeles, Los Angeles, Calif (A.M.); Department of Pathology, Children's Hospital Los Angeles, Los Angeles, Calif (A.J.); Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (P.d.B.); William S. Middleton Memorial Veterans Affairs (VA) Healthcare, Madison, Wis (P.T.); and Department of Radiology and Biomedical Engineering, University of Wisconsin-Madison, 750 Highland Ave, Madison, WI 53726 (P.T.).
Funding
UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Justine Yang Bruce · 1985 to 2026
$142.6MUniversity of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9MRadiomic spatial maps for identifying viable tumor extent on multi-parametric MRI for GlioblastomaR01CA277728 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Manmeet Ahluwalia, Pallavi Tiwari · 2024 to 2026
$3.0MQuantitative imaging phenotypic classifier for distinguishing radiation effects from tumor recurrence in Glioblastoma .R01CA264017 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Manmeet Ahluwalia, Pallavi Tiwari · 2022 to 2026
$2.9MRadxTools for assessing tumor treatment response on imagingU01CA248226 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI TIWARI, PALLAVI, VISWANATH, SATISH EASWAR · 2020 to 2022
$1.4MArtificial Intelligence-based decision support for chemotherapy-response assessment in Brain TumorsI01BX005842 · VA · WM S. MIDDLETON MEMORIAL VETERANS HOSP · PI TIWARI, PALLAVI · 2023 to 2025
–BLRD VA I01 BX005842Department of Defense W81XWH-18-1-0404NCATS NIH HHS UL1 TR002373NCI NIH HHS P30 CA014520NCI NIH HHS R01 CA264017NCI NIH HHS R01 CA277728NCI NIH HHS U01 CA248226
Abstract
Purpose To evaluate nnU-Net-based segmentation models for automated delineation of medulloblastoma tumors on multi-institutional MRI scans. Materials and Methods This retrospective study included 78 pediatric patients (52 male, 26 female), with ages ranging from 2 to 18 years, with medulloblastomas, from three different sites (28 from hospital A, 18 from hospital B, and 32 from hospital C), who had data available from three clinical MRI protocols (gadolinium-enhanced T1-weighted, T2-weighted, and fluid-attenuated inversion recovery). The scans were retrospectively collected from the year 2000 until May 2019. Reference standard annotations of the tumor habitat, including enhancing tumor, edema, and cystic core plus nonenhancing tumor subcompartments, were performed by two experienced neuroradiologists. Preprocessing included registration to age-appropriate atlases, skull stripping, bias correction, and intensity matching. The two models were trained as follows:
Indexed as
Cerebellar NeoplasmsMedulloblastomaMultiparametric Magnetic Resonance ImagingAdolescentChildChild, PreschoolDeep LearningFemaleHumansImage Interpretation, Computer-AssistedMaleNeural Networks, ComputerRetrospective StudiesMedulloblastomaMRIMR ImagingnnU-NetPediatricsSegmentationTransfer Learning
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