Evidence map›Paper›PMID 39166849›Full record

ArticlemSphere2024

Genetic evidence for a regulated cysteine protease catalytic triad in LegA7, a

Dar Hershkovitz, Emy J Chen, Alexander W Ensminger, Aisling S Dugan, Kaleigh T Conway, Alex C Joyce, Gil Segal, Ralph R Isberg

Abstract read
In one paragraph

Article in mSphere, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Dar Hershkovitz *The Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, Israel.
Emy J Chen *Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA.
Alexander W EnsmingerDepartment of Biochemistry, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0003-0824-3704
Aisling S DuganDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA.
Kaleigh T ConwayDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA.
Alex C JoyceDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA.
Gil SegalThe Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, Israel.ORCID 0000-0003-0392-253X
Ralph R IsbergDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA.ORCID 0000-0002-8330-3554

Funding

MEDICAL SCIENTIST TRAINING PROGRAM AT TUFTS UNIVERSITYT32GM008448 · NIGMS · TUFTS UNIVERSITY BOSTON · PI CHIN, MICHAEL T · 1994 to 2022
$9.1M
The role of ubiquitination in Legionella pneumophila infection and disease.F32AI074193 · NIAID · TUFTS UNIVERSITY BOSTON · PI ENSMINGER, ALEXANDER W · 2007 to 2009
$148k
Dissecting the Role of ERK and DUSP of Legionella pneumophila InfectionF32AI084202 · NIAID · TUFTS UNIVERSITY BOSTON · PI DUGAN, AISLING SIOBHAN · 2009 to 2009
$41k
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI46245NIAID NIH HHS F32 AI074193NIAID NIH HHS F32 AI084202NIGMS NIH HHS T32 GM008448United States-Israel Binational Science Foundation (BSF) 2019101
6 · The paper itself

Abstract

IMPORTANCE:

Indexed as

Bacterial ProteinsCysteine ProteasesLegionella pneumophilaCatalytic DomainHumansMutationSaccharomyces cerevisiaeStress, PhysiologicalBacterial ProteinsCysteine Proteasesankyrin repeatscysteine proteasesHOG pathwayLegionella pneumophilaMAP kinasesSaccharomyces cerevisiae

Identifiers

PMID39166849
PMCPMC11423584

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.