Evidence map›Paper›PMID 39166378›Full record

ArticleHead & neck2025

Morbidity of multimodal treatments including endoscopic surgery for sinonasal malignancies: Results of an international collaborative study on 940 patients (MUSES).

Giacomo Bertazzoni, Alessandro Vinciguerra, Domitille Camous, Marco Ferrari, Davide Mattavelli, Mario Turri-Zanoni, Alberto Schreiber, Stefano Taboni, Vittorio Rampinelli, Alberto Daniele Arosio and 8 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & neck, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Septal flip flap after endoscopic unilateral resection of sinonasal tumors: a multicenter experience of 133 patients.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  3. Article
  4. Article
  5. Sinonasal Sarcomas Management: An International Consensus Statement.International forum of allergy & rhinology · 2026
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Giacomo BertazzoniDepartment of Otorhinolaryngology, ASST Cremona, Cremona, Italy.
Alessandro VinciguerraDepartment of Otorhinolaryngology, Lariboisiere University Hospital, APHP Nord - Université De Paris, Paris, France.ORCID 0000-0003-4805-4908
Domitille CamousDepartment of Otorhinolaryngology, Lariboisiere University Hospital, APHP Nord - Université De Paris, Paris, France.
Marco FerrariUnit of Otorhinolaryngology-Head and Neck Surgery, Department of Neurosciences, Azienda Ospedale Università di Padova, University of Padua, Padua, Italy.ORCID 0000-0002-4023-0121
Davide MattavelliUnit of Otorhinolaryngology-Head and Neck Surgery, Department of Medical and Surgical Specialties, Radiologic Sciences, and Public Health, ASST Spedali Civili di Brescia, University of Brescia, Brescia, Italy.ORCID 0000-0001-7023-6746
Mario Turri-ZanoniDivision of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, ASST Lariana, Como, Italy.ORCID 0000-0002-3678-9088
Alberto SchreiberUnit of Otorhinolaryngology-Head and Neck Surgery, Department of Medical and Surgical Specialties, Radiologic Sciences, and Public Health, ASST Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
Stefano TaboniUnit of Otorhinolaryngology-Head and Neck Surgery, Department of Neurosciences, Azienda Ospedale Università di Padova, University of Padua, Padua, Italy.ORCID 0000-0003-2407-4031
Vittorio RampinelliUnit of Otorhinolaryngology-Head and Neck Surgery, Department of Medical and Surgical Specialties, Radiologic Sciences, and Public Health, ASST Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
Alberto Daniele ArosioDivision of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, ASST Sette Laghi, Varese, Italy.ORCID 0000-0002-8916-6562
Benjamin VerillaudDepartment of Otorhinolaryngology, Lariboisiere University Hospital, APHP Nord - Université De Paris, Paris, France.
Cesare PiazzaUnit of Otorhinolaryngology-Head and Neck Surgery, Department of Medical and Surgical Specialties, Radiologic Sciences, and Public Health, ASST Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
Paolo BattagliaDivision of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, ASST Lariana, Como, Italy.
Maurizio BignamiDivision of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, ASST Sette Laghi, Varese, Italy.
Alberto DeganelloOtolaryngology Head and Neck Surgery Department of IRCCS, National Cancer Institute (INT), Milan, Italy.ORCID 0000-0003-1008-7333
Paolo CastelnuovoDivision of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, ASST Sette Laghi, Varese, Italy.
Piero NicolaiUnit of Otorhinolaryngology-Head and Neck Surgery, Department of Neurosciences, Azienda Ospedale Università di Padova, University of Padua, Padua, Italy.
Philippe HermanDepartment of Otorhinolaryngology, Lariboisiere University Hospital, APHP Nord - Université De Paris, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIn the management of sinonasal malignancies treatment-induced morbidity and mortality is gaining relevance both for surgical approaches (endoscopic and open resection) and non-surgical therapies. The aim of this multicenter study is to assess complications associated with endoscopic surgery and non-surgical treatments (neoadjuvant and/or adjuvant) for malignant sinonasal tumors.

methodsAll patients with nasoethmoidal malignancies treated with curative intent with endoscopic or endoscopic-assisted surgery at three referral centers with uniform management policies were included. Neo- and/or adjuvant (chemo)radiotherapy was administered according to histology and pathological report. Demographics, treatment characteristics, and complications related both to the surgical and non-surgical approaches were retrieved. The data were analyzed with univariate and multivariate statistics to assess independent predictors of complications.

resultsNine hundred and forty patients were included, 643 males (68%) and 297 females (32%). A total of 225 complications were identified in 187 patients (19.9%): cerebrospinal fluid (CSF) leak (3.5%), mucocele (2.3%), surgical site bleeding (2.0%), epiphora (2.0%), and radionecrosis (2.0%) were the most common. Treatment-related mortality was 0.4%. Variables independently associated with complications at multivariate analysis were principally dural resection (OR 1.92), cranioendoscopic or multiportal resection (OR 2.93), dural repair with multilayer technique with less than three layers (OR 2.17), and graft different from iliotibial tract (OR 3.29).

conclusionOur study shows that modern endoscopic treatments and radiotherapy for sinonasal malignancies are associated with limited morbidity and treatment-related mortality. CSF leak and radionecrosis, although rare, remain the most frequent complications and should be further addressed by future research efforts.

Indexed as

EndoscopyParanasal Sinus NeoplasmsAdolescentAdultAgedAged, 80 and overCombined Modality TherapyFemaleHumansMaleMiddle AgedMultivariate AnalysisNeoadjuvant TherapyPostoperative ComplicationsRetrospective StudiesTreatment Outcomeanterior skull baseendoscopic resectionsinonasal malignanciestranscribriform approachtransnasal craniectomy

Identifiers

PMID39166378
PMCPMC11635746

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.