Evidence map›Paper›PMID 39166327›Full record

Trial reportCirculation2024

Effect of Colchicine on Coronary Plaque Stability in Acute Coronary Syndrome as Assessed by Optical Coherence Tomography: The COLOCT Randomized Clinical Trial.

Miao Yu, Yong Yang, Si-Lai Dong, Chen Zhao, Fen Yang, Yuan-Fan Yuan, Yu-Hua Liao, Shao-Lin He, Kun Liu, Fen Wei and 3 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Circulation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04848857 (The Efficacy and Safety of Colchicine in Improving the Stability of Coronary Plaque in Patients With Acute Coronary Syndrome), which is not on this map. Cited by 61 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04848857 phase4completednot on this map

The Efficacy and Safety of Colchicine in Improving the Stability of Coronary Plaque in Patients With Acute Coronary Syndrome

TypeinterventionalSponsorUnion Hospital, Tongji Medical College, Huazhong University of Science and TechnologyRan2021 to 2023Enrolled128ConditionsAcute Coronary SyndromeArmsColchicine, Placebo
3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Colchicine in Coronary Artery Disease-Too Much of a Good Thing?Journal of cardiovascular development and disease · 2026
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Miao Yu *Department of Cardiology (M.Y., Y.Y., S.-L.D., F.Y., Y.-F.Y., Y.-H.L., S.-L.H., K.L., F.W., X.C.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID 0000-0002-8298-1679
Yong Yang *Department of Cardiology (M.Y., Y.Y., S.-L.D., F.Y., Y.-F.Y., Y.-H.L., S.-L.H., K.L., F.W., X.C.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID 0009-0002-2940-372X
Si-Lai Dong *Department of Cardiology (M.Y., Y.Y., S.-L.D., F.Y., Y.-F.Y., Y.-H.L., S.-L.H., K.L., F.W., X.C.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID 0000-0002-2786-2685
Chen Zhao *Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, China (C.Z., H.-B.J., B.Y.).ORCID 0000-0002-6753-7000
Fen YangDepartment of Cardiology (M.Y., Y.Y., S.-L.D., F.Y., Y.-F.Y., Y.-H.L., S.-L.H., K.L., F.W., X.C.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID 0000-0001-6050-9448
Yuan-Fan YuanDepartment of Cardiology (M.Y., Y.Y., S.-L.D., F.Y., Y.-F.Y., Y.-H.L., S.-L.H., K.L., F.W., X.C.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID 0000-0001-6628-0234
Yu-Hua LiaoDepartment of Cardiology (M.Y., Y.Y., S.-L.D., F.Y., Y.-F.Y., Y.-H.L., S.-L.H., K.L., F.W., X.C.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID 0000-0002-7787-2953
Shao-Lin HeDepartment of Cardiology (M.Y., Y.Y., S.-L.D., F.Y., Y.-F.Y., Y.-H.L., S.-L.H., K.L., F.W., X.C.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID 0000-0001-9961-0551
Kun LiuDepartment of Cardiology (M.Y., Y.Y., S.-L.D., F.Y., Y.-F.Y., Y.-H.L., S.-L.H., K.L., F.W., X.C.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID 0000-0002-4919-9896
Fen WeiDepartment of Cardiology (M.Y., Y.Y., S.-L.D., F.Y., Y.-F.Y., Y.-H.L., S.-L.H., K.L., F.W., X.C.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Hai-Bo JiaDepartment of Cardiology, Second Affiliated Hospital of Harbin Medical University, China (C.Z., H.-B.J., B.Y.).ORCID 0000-0001-9968-4024
Bo YuDepartment of Cardiology, Second Affiliated Hospital of Harbin Medical University, China (C.Z., H.-B.J., B.Y.).ORCID 0000-0002-5955-6332
Xiang ChengDepartment of Cardiology (M.Y., Y.Y., S.-L.D., F.Y., Y.-F.Y., Y.-H.L., S.-L.H., K.L., F.W., X.C.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID 0000-0002-6287-3128

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundColchicine has been approved to reduce cardiovascular risk in patients with coronary heart disease on the basis of its potential benefits demonstrated in the COLCOT (Colchicine Cardiovascular Outcomes Trial) and LoDoCo2 (Low-Dose Colchicine 2) studies. Nevertheless, there are limited data available about the specific impact of colchicine on coronary plaques.

methodsThis was a prospective, single-center, randomized, double-blind clinical trial. From May 3, 2021, until August 31, 2022, a total of 128 patients with acute coronary syndrome aged 18 to 80 years with lipid-rich plaque (lipid pool arc >90°) detected by optical coherence tomography were included. The subjects were randomly assigned in a 1:1 ratio to receive either colchicine (0.5 mg once daily) or placebo for 12 months. The primary end point was the change in the minimal fibrous cap thickness from baseline to the 12-month follow-up.

resultsAmong 128 patients, 52 in the colchicine group and 52 in the placebo group completed the study. The mean age of the 128 patients was 58.0±9.8 years, and 25.0% were female. Compared with placebo, colchicine therapy significantly increased the minimal fibrous cap thickness (51.9 [95% CI, 32.8 to 71.0] μm versus 87.2 [95% CI, 69.9 to 104.5] μm; difference, 34.2 [95% CI, 9.7 to 58.6] μm;

conclusionsOur findings suggested that colchicine resulted in favorable effects on coronary plaque stabilization at optical coherence tomography in patients with acute coronary syndrome. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT04848857.

Indexed as

Acute Coronary SyndromeColchicinePlaque, AtheroscleroticTomography, Optical CoherenceAdultAgedCoronary Artery DiseaseDouble-Blind MethodFemaleHumansMaleMiddle AgedProspective StudiesTreatment OutcomeColchicineacute coronary syndromescolchicineinflammationoptical coherence tomography

Identifiers

PMID39166327

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.