Evidence map›Paper›PMID 39166121›Full record

ArticleHealth science reports2024

Characteristic calcification behavior of five surgical aortic valve bioprostheses models: An in vitro study.

Najla Sadat, John H Lojenburg, Michael Scharfschwerdt, Matthias Klinger, Buntaro Fujita, Stephan Ensminger

Abstract read
In one paragraph

Article in Health science reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Najla SadatDepartment of Cardiac and Thoracic Vascular Surgery University Medical Center Schleswig-Holstein Lübeck Germany.ORCID 0000-0002-2715-1760
John H LojenburgDepartment of Cardiac and Thoracic Vascular Surgery University Medical Center Schleswig-Holstein Lübeck Germany.
Michael ScharfschwerdtDepartment of Cardiac and Thoracic Vascular Surgery University Medical Center Schleswig-Holstein Lübeck Germany.
Matthias KlingerInstitute for Anatomy, Medical Faculty University of Lübeck Lübeck Germany.
Buntaro FujitaDepartment of Cardiac and Thoracic Vascular Surgery University Medical Center Schleswig-Holstein Lübeck Germany.
Stephan EnsmingerDepartment of Cardiac and Thoracic Vascular Surgery University Medical Center Schleswig-Holstein Lübeck Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: The durability of surgical aortic valve bioprostheses (SAV) is limited by the calcification of the leaflets, which results in degeneration. In clinical routine, there seems to be substantial variability in the degeneration of specific SAV models. Our study aims to establish an in vitro calcification model for prosthetic valves, characterizing the calcification behavior of different SAVs. Methods: Five commercially available SAV models (Epic™ Supra, Freestyle®, Intuity®, Perimount®, and Trifecta™) were perfused with double-distilled water and physiological buffer with a defined calcium concentration (CaCl Results: Treatment in the Hi-Cycle tester with calcification buffer maintained significantly higher calcium absorption of SAVs compared to the control group ( Conclusion: Data from our study revealed significant differences in leaflet calcification for the various aortic valve bioprostheses models. Further studies are necessary to investigate whether these findings can mimic the clinical data of the implanted prostheses.

Indexed as

bioprostheses degenerationcalcificationdurability testingstructural valve deteriorationsurgical aortic valve

Identifiers

PMID39166121
PMCPMC11333945

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.