ArticleFrontiers in cellular and infection microbiology2024
Molecular epidemiology of string test-positive Klebsiella pneumoniae isolates in Huzhou, China, 2020-2023.
Article in Frontiers in cellular and infection microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed.
- ElevatedEmerging microbes & infections · 2026Article
- Complete genome sequence of an MDR and hypermucoviscousMicrobiology resource announcements · 2026Article
- Molecular Epidemiology ofMicroorganisms · 2026Article
- The promising activity of apple cider vinegar on MDR Klebsiella spp. (K. variicola and K. pneumoniae) emerging pathogens in chicken.Veterinary research communications · 2025Article
- Antimicrobial Resistance and Genomic Characterization of Salmonella Serovars Typhimurium and 4,[5],12:i:- in Huzhou, China.Infection and drug resistance · 2025Article
- Molecular analysis ofOpen veterinary journal · 2025Article
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Abstract
Objective: This study used whole-genome sequencing (WGS) to explore the genetic diversity, virulence factors, and antimicrobial resistance determinants of string test-positive Methods: In total, 632 clinical isolates were collected via hospital surveillance from 2020 to 2023; 100 were positive in the string test and these 100 strains were subjected to antimicrobial susceptibility testing using an agar dilution method followed by WGS. Results: The resistance rates to cefotaxime (77.0%), trimethoprim-sulfamethoxazole (67.0%), and nalidixic acid (64.0%) were high. Multilocus sequence typing revealed high genetic diversity; there were 33 sequence types (STs) and 15 capsular serotypes. The most common ST was ST23 (16.0%) and the most common capsular serotype was K1 (22.5%). Virulome analysis revealed among-strain differences in virulence factors that affected bacterial adherence, efflux pump action, iron uptake, nutritional factors, metabolic regulation, the secretion system, and toxin production. The Kleborate strain-specific virulence scores of all 100 string test-positive KPs were derived: 28 strains scored 5, 28 scored 4, 21 scored 3, 12 scored 1, and 11 scored 0. All 77 strains with scores of 3 to 5 contained the Conclusion: The present study highlights the significance of the KP
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