ArticleWorld journal of orthopedics2024
Blood metal concentrations and cardiac structure and function in total joint arthroplasty patients.
Article in World journal of orthopedics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Long-Term Risk of Heart Failure in Total Joint Arthroplasty: A Population-Based Cohort Study.The Journal of arthroplasty · 2025Article
- Primary Total Knee Arthroplasty for Bullet-Induced Lead Arthropathy.Arthroplasty today · 2025Article
- Cardiotoxicity concerns in total joint arthroplasty.World journal of orthopedics · 2024Article
- Association between metallic implants and stroke in US adults from NHANES 2015-2023 a cross-sectional study.Frontiers in aging neuroscience · 2024Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is concern regarding potential long-term cardiotoxicity with systemic distribution of metals in total joint arthroplasty (TJA) patients.
aimTo determine the association of commonly used implant metals with echocardiographic measures in TJA patients.
methodsThe study comprised 110 TJA patients who had a recent history of high chromium, cobalt or titanium concentrations. Patients underwent two-dimensional, three-dimensional, Doppler and speckle-strain transthoracic echocardiography and a blood draw to measure metal concentrations. Age and sex-adjusted linear and logistic regression models were used to examine the association of metal concentrations (exposure) with echocardiographic measures (outcome).
resultsHigher cobalt concentrations were associated with increased left ventricular end-diastolic volume (estimate 5.09; 95%CI: 0.02-10.17) as well as left atrial and right ventricular dilation, particularly in men but no changes in cardiac function. Higher titanium concentrations were associated with a reduction in left ventricle global longitudinal strain (estimate 0.38; 95%CI: 0.70 to 0.06) and cardiac index (estimate 0.08; 95%CI, -0.15 to -0.01).
conclusionElevated cobalt and titanium concentrations may be associated with structural and functional cardiac changes in some patients. Longitudinal studies are warranted to better understand the systemic effects of metals in TJA patients.
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