Evidence map›Paper›PMID 39165600›Full record

ArticleReports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology2024

Adjuvant radiotherapy after brain metastasectomy: analysis of consecutive cohort of 118 patients from real world practice.

Pavel Fadrus, Vaclav Vybihal, Ivana Roskova, Iveta Selingerova, Martin Smrcka, Radim Jancalek, Jiri Sana, Ondrej Slaby, Petr Pospisil, Ludmila Hynkova and 17 more

Abstract read
In one paragraph

Article in Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Pavel Fadrus *Department of Neurosurgery, University Hospital Brno, Czech Republic.
Vaclav Vybihal *Department of Neurosurgery, University Hospital Brno, Czech Republic.
Ivana RoskovaDepartment of Neurosurgery, University Hospital Brno, Czech Republic.
Iveta SelingerovaResearch Center for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
Martin SmrckaDepartment of Neurosurgery, University Hospital Brno, Czech Republic.
Radim JancalekDepartment of Neurosurgery, St. Anne's University Hospital Brno, Brno, Czech Republic.
Jiri SanaDepartment of Biology, Faculty of Medicine, Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
Ondrej SlabyDepartment of Biology, Faculty of Medicine, Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
Petr PospisilDepartment of Radiation Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
Ludmila HynkovaDepartment of Radiation Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
Jan GarcicDepartment of Radiation Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
Renata BelanovaDepartment of Radiology, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
Jan KristekDepartment of Radiology, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
Andrea Sprlakova-PukovaDepartment of Radiology and Nuclear Medicine, University Hospital Brno and Masaryk University, Brno, Czech Republic.
Zdenek MackerleDepartment of Neurosurgery, St. Anne's University Hospital Brno, Brno, Czech Republic.
Vilem JuranDepartment of Neurosurgery, University Hospital Brno, Czech Republic.
Marek SovaDepartment of Neurosurgery, University Hospital Brno, Czech Republic.
Eduard NeumanDepartment of Neurosurgery, University Hospital Brno, Czech Republic.
Hana ValekovaDepartment of Neurosurgery, St. Anne's University Hospital Brno, Brno, Czech Republic.
Radek LakomyDepartment of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
Milos HolanekDepartment of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
Roman HrstkaResearch Center for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
Michaela SvajdovaDepartment of Radiation Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
Katerina PolachovaDepartment of Radiation Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
Ivana KolouskovaDepartment of Comprehensive Cancer Care, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Pavel SlampaDepartment of Radiation Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
Tomas KazdaResearch Center for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The aim of this retrospective study is to analyze a consecutive cohort of brain metastasis (BM) patients treated off clinical trials through combination of surgery and radiotherapy over the last 15 years in a tertiary neurooncology center. Materials and methods: All BM patients operated between 2007-2019 received adjuvant linac-based radiotherapy categorized to whole brain radiotherapy (WBRT) and tumor bed stereotactic radiotherapy. Survival outcomes and local control was analyzed. Results: In total, 118 patients were enrolled, those with stereotactic radiotherapy (41%) had better baseline characteristics mirrored in longer overall survival (OS) [18 Conclusions: Real world data demonstrating significantly better overall survival in patients treated with postoperative targeted radiotherapy compared with postoperative WBRT is presented, with no significant difference in cumulative incidence for local or distant brain control. The majority of patients with targeted radiotherapy had a fractionated dose schedule with outcomes comparable to single-dose radiation trials of postoperative targeted radiotherapy.

Indexed as

brain metastasesoverall survivalradiotherapysurgerytumor cavity

Identifiers

PMID39165600
PMCPMC11333081

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.