Evidence map›Paper›PMID 39165448›Full record

ReviewCureus2024

Efficacy of Glucagon-Like Peptide 1 (GLP-1) Receptor Agonists for Weight Loss Management in Non-Diabetic Patients.

Ilma Vahora, Kiran Prasad Moparthi, Majdah T Al Rushaidi, Meghana Reddy Muddam, Omobolanle A Obajeun, Abdelrahman Abaza, Arturo P Jaramillo, Faten Sid Idris, Humna Anis Shaikh, Lubna Mohammed

Abstract readReview
In one paragraph

Review in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ilma VahoraInternal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Kiran Prasad MoparthiGeneral Practice, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Majdah T Al RushaidiPsychology, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Meghana Reddy MuddamGeneral Practice, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Omobolanle A ObajeunPediatrics, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Abdelrahman AbazaPathology, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Arturo P JaramilloGeneral Practice, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Faten Sid IdrisPediatrics, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Humna Anis ShaikhPediatrics, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Lubna MohammedInternal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rising prevalence of obesity has led to a poor quality of life affecting millions worldwide. The lack of a healthy diet and exercise intervention are the major risk factors leading to obesity, as well as genetics. Obesity can lead to type 2 diabetes mellitus. However, there are many people who are obese and do not have an established diagnosis of diabetes but want to reduce their body weight to improve their quality of life. This review aims to discuss the efficacy of the diabetic pharmacologic agents, glucagon-like peptide-1 (GLP-1) receptor agonists, on body weight. The review follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines 2020 and includes a comprehensive search strategy. The articles gathered are from the last five to 10 years. The articles are collected from distinguished databases such as PubMed, Google Scholar, ResearchGate, and Science Direct. Of the 698 studies identified based on the screening methods, 22 were assessed for eligibility and 10 studies were included in the final review. The findings of this systematic review provide a bigger picture of the efficacy and safety of glucagon-like peptide receptor agonist agents. The review thoroughly discusses the risk factors for obesity and provides a treatment strategy that can be utilized in clinical practice in the future. The review concludes that glucagon-like peptide agents act as pharmacologic treatments for reduction in body weight and also serve as cardioprotective agents.

Indexed as

diabetesendocrinologyglucagon-like peptide receptor agonistsobesityweight loss

Identifiers

PMID39165448
PMCPMC11335185

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.