Evidence map›Paper›PMID 39165439›Full record

ReviewCureus2024

Is Low-Dose Lung Radiotherapy for Severe COVID-19 Pneumonia a Therapeutic Alternative?

Fatima Safini, Bouchra Amaoui, Kenza Oqbani, Sanae Abbaoui, Slimane Semghouli

Abstract readReview
In one paragraph

Review in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fatima SafiniDepartment of Radiation Therapy, Souss-Massa University Hospital, Agadir, MAR.
Bouchra AmaouiDepartment of Radiation Therapy, Souss-Massa University Hospital, Agadir, MAR.
Kenza OqbaniFaculty of Medicine and Pharmacy, Ibn Zohr University, Agadir, MAR.
Sanae AbbaouiFaculty of Medicine and Pharmacy, Ibn Zohr University, Agadir, MAR.
Slimane SemghouliMedical Physics, Higher Institute of Nursing Professions and Health Techniques, Agadir, MAR.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Low-dose radiotherapy (LD-RT) has historically been used to treat severe bacterial and viral pneumonia due to its immunomodulatory properties. However, this technique has been delayed since the advent of antibiotics and the carcinogenic risk associated with radiation therapy. Currently, it represents an alternative therapeutic in the SARS-CoV-2 pandemic which leads sometimes to fatal pneumonia, especially given the limited availability of effective treatments for severe forms of pneumonia. Numerous in vitro and in vivo studies have demonstrated the anti-inflammatory effect of LD-RT and have reported clinical and biological improvement in patients with severe pneumonia. In this literature review, we report the data and results of various published clinical trials.

Indexed as

covid-19low doselung radiotherapypneumoniasars-cov-2

Identifiers

PMID39165439
PMCPMC11334754

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.