Evidence map›Paper›PMID 39165398›Full record

ArticleRheumatology advances in practice2024

British Axial Spondyloarthritis Inception Cohort (BAxSIC): a protocol for a multicentre real-world observational cohort study of early axial spondyloarthritis.

Jake Weddell, Stephanie R Harrison, Alexander N Bennett, Karl Gaffney, Gareth T Jones, Pedro M Machado, Jonathan Packham, Raj Sengupta, Sizheng Steven Zhao, Stefan Siebert and 1 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Rheumatology advances in practice, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05676775 (British Axial Spondyloarthritis Inception Cohort), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05676775 recruitingnot on this map

British Axial Spondyloarthritis Inception Cohort

TypeobservationalSponsorThe Leeds Teaching Hospitals NHS TrustRan2023 to 2029Enrolled500ConditionsAxial SpondyloarthritisArmsNo intervenetion
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jake WeddellNIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK.ORCID https://orcid.org/0000-0002-9913-9082
Stephanie R HarrisonNIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK.ORCID https://orcid.org/0000-0002-7465-2621
Alexander N BennettNational Heart and Lung Institute, Faculty of Medicine, Imperial College, London, UK.ORCID https://orcid.org/0000-0003-2985-5304
Karl GaffneyNorfolk and Norwich University Hospital NHS Foundation Trust and Norwich Medical School, University of East Anglia, Norwich, UK.ORCID https://orcid.org/0000-0002-7863-9176
Gareth T JonesAberdeen Centre for Arthritis and Musculoskeletal Health (Epidemiology Group), University of Aberdeen, Aberdeen, UK.ORCID https://orcid.org/0000-0003-0016-7591
Pedro M MachadoDepartment of Neuromuscular Diseases and Centre for Rheumatology, University College London, London, UK.ORCID https://orcid.org/0000-0002-8411-7972
Jonathan PackhamUnit of Population and Lifespan Sciences, University of Nottingham, Nottingham, UK.ORCID https://orcid.org/0000-0001-5531-1680
Raj SenguptaRoyal National Hospital for Rheumatic Diseases, Royal United Hospitals, Bath, UK.ORCID https://orcid.org/0000-0002-9720-0396
Sizheng Steven ZhaoDivision of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, UK.ORCID https://orcid.org/0000-0002-3558-7353
Stefan SiebertSchool of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.ORCID https://orcid.org/0000-0002-1802-7311
Helena Marzo-OrtegaNIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK.ORCID https://orcid.org/0000-0002-9683-3407

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Timely diagnosis remains a challenge in axial SpA (axSpA). In addition, data are scarce on the impact of diagnostic delay and disease progression in affected individuals. The British Axial Spondyloarthritis Inception Cohort (BAxSIC) study aims to investigate the impact of newly diagnosed axSpA, the natural history of the disease and the effect of diagnostic delay on disease outcomes. Methods: BAxSIC is a prospective, multicentre, observational study. Eligible participants are adults (≥16 years of age), with a physician-confirmed diagnosis of axSpA in the 6 months prior to study entry, recruited from secondary and tertiary rheumatology centres in the UK. Participants will be followed up for 3 years, with in-person visits at baseline and 24 months. In addition, patient self-reported assessments will be recorded remotely via the online electronic case report form (eCRF) at 6, 12, 18, 30 and 36 months. Results: The first patient was enrolled in BAxSIC in June 2023. Recruitment is currently ongoing and is planned to end in June 2026. Initial results will be available in 2027. Since opening, the trial has undergone two protocol amendments. Conclusion: The BAxSIC study is the first inception cohort designed to investigate the impact of diagnostic delay on clinical presentation and long-term functional outcomes in patients with axSpA in the UK. With an innovative, patient-led virtual longitudinal data collection model, data generated from this study will help inform and improve the care of people newly diagnosed with axSpA. Trial registration: ClinicalTrials.gov (http://clinicaltrials.gov), NCT05676775.

Indexed as

axial spondyloarthritisdiagnostic delayinception cohortrheumatologyvirtual follow-up

Identifiers

PMID39165398
PMCPMC11333759

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.