Evidence map›Paper›PMID 39165160›Full record

SynthesisClinical and molecular hepatology2024

Assessment of the postoperative prognosis in patients with hepatocellular carcinoma using vibration-controlled transient elastography: A systemic review and meta-analysis.

Jung Hwan Yu, Ji Won Han, Young Ju Suh, Young Eun Chon, Hee Yeon Kim, Ji Hyun An, Young-Joo Jin, Miyoung Choi, Seung Up Kim, Dae Won Jun and 2 more

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical and molecular hepatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Jung Hwan YuDepartment of Internal Medicine, Inha University Hospital and School of Medicine, Incheon, Korea.
Ji Won HanThe Catholic University Liver Research Center, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Young Ju SuhDepartment of Biomedical Sciences, College of Medicine, Inha University, Incheon, Korea.
Young Eun ChonDepartment of Gastroenterology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
Hee Yeon KimDepartment of Internal Medicine, College of Medicine, Bucheon St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.
Ji Hyun AnDepartment of Gastroenterology and Hepatology, Hanyang University College of Medicine, Guri, Korea.
Young-Joo JinDepartment of Internal Medicine, Inha University Hospital and School of Medicine, Incheon, Korea.
Miyoung ChoiClinical Evidence Research, National Evidence-based Healthcare Collaborating Agency (NECA), Seoul, Korea.
Seung Up KimDepartment of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Dae Won JunDepartment of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
Han Ah LeeDepartment of Internal Medicine, College of Medicine, Chung-Ang University Hospital, Seoul, Korea.
Mi Na KimDepartment of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Funding

Korea Health Industry Development InstituteMinistry of EducationMinistry of Health and Welfare HI23C1489National Research Foundation of Korea 2022R1I1A1A01063636
6 · The paper itself

Abstract

BACKGROUNDS/

aimsThis meta-analysis examined whether preoperative vibration-controlled transient elastography (VCTE) can predict postoperative complications and recurrence in patients undergoing hepatic resection for hepatocellular carcinoma (HCC).

methodsA systematic literature search was conducted using Ovid-Medline, EMBASE, Cochrane, and KoreaMed databases. Out of 431 individual studies, thirteen published between 2008 and 2022 were included. Five studies focused on HCC recurrence, while eight examined postoperative complications.

resultsThe meta-analysis of five studies on HCC recurrence showed that the high-risk group with a high VCTE score had a significantly increased recurrence rate after hepatic resection (hazard ratio 2.14). The cutoff value of VCTE in the high-risk group of HCC recurrence was 7.4-13.4 kPa, the sensitivity was 0.60 (95% confidence interval [CI] 0.47-0.72), and the specificity was 0.60 (95% CI 0.46-0.72). The area under the receiver operating characteristic curve (AUC) of the liver stiffness measured by VCTE to predict the HCC recurrence was 0.63 (95% CI 0.59-0.67). The meta-analysis on the postoperative complications revealed a significantly increased risk of postoperative complications in the high-risk group (12-25.6 kPa) with a high VCTE value (odds ratio [OR], 8.32). The AUC of the liver stiffness measured by VCTE to predict the postoperative complications was 0.87 (95% CI 0.84-0.90), the sensitivity was 0.76 (95% CI 0.55-0.89) and the specificity was 0.85 (95% CI 0.73-0.92).

conclusionThis meta-analysis suggests that preoperative VCTE in patients undergoing hepatic resection for HCC is useful in identifying individuals at a high risk of postoperative complications and HCC recurrence.

Indexed as

Carcinoma, HepatocellularElasticity Imaging TechniquesLiver NeoplasmsNeoplasm Recurrence, LocalPostoperative ComplicationsVibrationArea Under CurveHepatectomyHumansPrognosisROC CurveHepatocellular carcinomaNoninvasive testTransient elastography

Identifiers

PMID39165160
PMCPMC11493357

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.