Evidence map›Paper›PMID 39164947›Full record

ReviewClinical pharmacology and therapeutics2025

Towards Preanalytical Best Practices for Liquid Biopsy Studies: A BLOODPAC Landscape Analysis.

Christina M Lockwood, Jason D Merker, Elizabeth Bain, Caroline Compton, Robert L Grossman, Donald Johann, Frederick Jones, Gregory Jones, Matthew Kreifels, Suzanne LeBlang and 9 more

Abstract readReview
In one paragraph

Review in Clinical pharmacology and therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Advances in laboratory medicine · 2025
    Article
  9. Review
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Christina M Lockwood *Association for Molecular Pathology, Rockville, Maryland, USA.ORCID 0000-0001-9036-7604
Jason D Merker *American Society of Clinical Oncology, Alexandria, Virginia, USA.ORCID 0000-0002-0865-3394
Elizabeth BainAmerican Cancer Society, Atlanta, Georgia, USA.ORCID 0009-0003-2543-9394
Caroline ComptonSchool of Life Sciences, Arizona State University, Phoenix, Arizona, USA.ORCID 0000-0002-6904-2765
Robert L GrossmanOpen Commons Consortium, Chicago, Illinois, USA.ORCID 0000-0003-3741-5739
Donald JohannCollege of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Frederick JonesSysmex Inostics Inc, Baltimore, Maryland, USA.ORCID 0000-0002-6534-8206
Gregory JonesNeogenomics, Fort Myers, Florida, USA.
Matthew KreifelsStreck, Omaha, Nebraska, USA.
Suzanne LeBlangFocused Ultrasound Foundation, Charlottesville, Virginia, USA.
Jerry S H LeeEllison Institute of Technology, University of Southern California, Los Angeles, California, USA.ORCID 0000-0003-1515-0952
John LylePersonalis, Fremont, California, USA.
Jean-Francois MartiniPfizer, San Diego, California, USA.ORCID 0000-0001-8570-1401
Lauren SaundersCeres Nanosciences, Manassas, Virginia, USA.ORCID 0009-0003-3498-6496
Howard ScherMemorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID 0000-0002-6791-9324
Stella SomiariWindber Research Institute, Windber, Pennsylvania, USA.ORCID 0000-0002-7170-9098
Mark StewartFriends of Cancer Research, Washington, District of Columbia, USA.ORCID 0000-0002-4847-0736
Jacob VinsonProstate Cancer Clinical Trials Consortium, New York, New York, USA.ORCID 0009-0000-0405-7854
Lauren C LeimanBLOODPAC, Chicago, Illinois, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

BLOODPAC is a public-private consortium that develops best practices, coordinates clinical and translational research, and manages the BLOODPAC Data Commons to broadly support the liquid biopsy community and accelerate regulatory review to aid patient accessibility. BLOODPAC previously recommended 11 preanalytical minimal technical data elements (MTDEs) for BLOODPAC-sponsored studies and data submitted to BLOODPAC Data Commons. The current landscape analysis evaluates the overlap of the BLOODPAC MTDEs with current best practices, guidelines, and standards documents related to clinical and research liquid biopsy applications. Our findings indicate an existing high degree of concordance among these documents. Where differences exist, the BLOODPAC preanalytical MTDEs can be considered a minimal practicable set for organizations to utilize. These MTDEs were developed following extensive examination of best practices and iterative conversations with the U.S. FDA. BLOODPAC recommends the use of these MTDEs in submissions to data commons and to support liquid biopsy clinical trials and research globally.

Indexed as

Practice Guidelines as TopicHumansLiquid BiopsyPublic-Private Sector PartnershipsTranslational Research, BiomedicalUnited States

Identifiers

PMID39164947
PMCPMC11652819

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.