The activity-regulated cytoskeleton-associated protein (Arc) functions in a cell type- and sex-specific manner in the adult nucleus accumbens to regulate non-contingent cocaine behaviors.
Article in Genes, brain, and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
12 authors.
Daniel J WoodDepartment of Neuroscience, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID 0000-0003-1874-7738
Jessica L HuebschmanDepartment of Neuroscience, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID 0000-0003-1979-4341
Dalia MartinezDepartment of Neuroscience, Medical University of South Carolina, Charleston, South Carolina, USA.
Evgeny TsvetkovDepartment of Neuroscience, Medical University of South Carolina, Charleston, South Carolina, USA.
Kirsten SnyderDepartment of Neuroscience, Medical University of South Carolina, Charleston, South Carolina, USA.
Raymond TjhiaDepartment of Neuroscience and Experimental Therapeutics, Texas A&M University Health Science Center, Bryan, Texas, USA.
Jaswinder KumarDepartment of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, USA.
Brandon W HughesDepartment of Neuroscience, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID 0000-0002-2742-6453
Makoto TaniguchiDepartment of Neuroscience, Medical University of South Carolina, Charleston, South Carolina, USA.
Laura N SmithDepartment of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, USA.ORCID 0000-0003-3687-3148
Christopher W CowanDepartment of Neuroscience, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID 0000-0001-5472-3296
Rachel D PenrodDepartment of Neuroscience, Medical University of South Carolina, Charleston, South Carolina, USA.
Funding
DRUG ABUSE TRAINING PROGRAMT32DA007288 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Christopher W Cowan, Rachel Penrod-Martin · 1991 to 2026
$11.8M
The Role of Early Life Stress in Feeding BehaviorsP20GM148302 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Jose H Ledo · 2023 to 2026
$11.5M
COCA: Project 4. Neurocircuit Strategy to Decrease Cocaine Cue ReactivityP50DA046373 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI HANLON, COLLEEN A · 2019 to 2023
$9.9M
Interdisciplinary Women's Health Research at MUSCK12HD055885 · NICHD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MCGINTY, JACQUELINE F. · 2007 to 2021
$7.2M
Role of Class IIa HDAC Target Genes in Opioid and Cocaine AddictionR01DA032708 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI COWAN, CHRISTOPHER W · 2013 to 2022
$3.8M
Transcriptional Mechanisms of Addiction-Related Neural PlasticityR01DA027664 · NIDA · UT SOUTHWESTERN MEDICAL CENTER · PI COWAN, CHRISTOPHER W · 2011 to 2021
$3.6M
Activity-regulated cytoskeleton-associated protein mediates nucleus accumbens function via cell type-specific action”R21MH123883 · NIMH · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI PENROD-MARTIN, RACHEL · 2020 to 2020
$411k
Epigenetic mechanimsms in cocaine rewardF32DA036319 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI PENROD-MARTIN, RACHEL · 2014 to 2016
Repeated cocaine use produces adaptations in brain function that contribute to long-lasting behaviors associated with cocaine use disorder (CUD). In rodents, the activity-regulated cytoskeleton-associated protein (Arc) can regulate glutamatergic synaptic transmission, and cocaine regulates Arc expression and subcellular localization in multiple brain regions, including the nucleus accumbens (NAc)-a brain region linked to CUD-related behavior. We show here that repeated, non-contingent cocaine administration in global Arc KO male mice produced a dramatic hypersensitization of cocaine locomotor responses and drug experience-dependent sensitization of conditioned place preference (CPP). In contrast to the global Arc KO mice, viral-mediated reduction of Arc in the adult male, but not female, NAc (shArc
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
The activity-regulated cytoskeleton-associated protein (Arc) functions in a cell type- and sex-specific manner in the adult nucleus accumbens to regulate non-contingent cocaine behaviors. · full record | OpenQuestion