Evidence map›Paper›PMID 39164826›Full record

ArticleJournal of cellular and molecular medicine2024

CD248-expressing cancer-associated fibroblasts induce non-small cell lung cancer metastasis via Hippo pathway-mediated extracellular matrix stiffness.

Jiangwei Wu, Qiaoling Zhang, Zeyang Yang, Yujun Xu, Xinlei Liu, Xuanying Wang, Jiangying Peng, Jing Xiao, Yun Wang, Zhenling Shang and 7 more

Abstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jiangwei WuDepartment of Immunology, Guizhou Medical University, Guiyang, China.
Qiaoling ZhangDepartment of Immunology, Guizhou Medical University, Guiyang, China.
Zeyang YangDepartment of Immunology, Guizhou Medical University, Guiyang, China.
Yujun XuDepartment of Biology, Guizhou Medical University, Guiyang, China.
Xinlei LiuGuizhou Prenatal Diagnsis Center, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Xuanying WangDepartment of Immunology, Guizhou Medical University, Guiyang, China.
Jiangying PengDepartment of Pharmaceutical Analysis, Zunyi Medical University, Zunyi, China.
Jing XiaoDepartment of Immunology, Guizhou Medical University, Guiyang, China.
Yun WangImmune Cells and Antibody Engineering Research Center of Guizhou Province, Key Laboratory of Biology and Medical Engineering, Guizhou Medical University, Guiyang, China.
Zhenling ShangDepartment of Immunology, Guizhou Medical University, Guiyang, China.
Nianxue WangDepartment of Immunology, Guizhou Medical University, Guiyang, China.
Long LiDepartment of Immunology, Guizhou Medical University, Guiyang, China.
Rui ZhangDepartment of Immunology, Guizhou Medical University, Guiyang, China.
Wei ZhangDepartment of Biochemistry and Molecular Biology, Jilin Medical University, Jilin, China.
Jian ZhangDepartment of Thoracic Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Zhu ZengDepartment of Immunology, Guizhou Medical University, Guiyang, China.
Jieheng WuDepartment of Immunology, Guizhou Medical University, Guiyang, China.ORCID 0000-0003-4927-3897

Funding

National Natural Science Foundation of China 12132006National Natural Science Foundation of China 32371373National Natural Science Foundation of China 82160566National Natural Science Foundation of China Cultivation Program of Guizhou Medical University 21NSFCP26Project of the Jilin Provincial Department of Education's Basic Research Program JT53101022010the Flexible Talent Introduction Project of Guizhou Medical University RN2021-GK045
6 · The paper itself

Abstract

Metastasis is a crucial stage in tumour progression, and cancer-associated fibroblasts (CAFs) support metastasis through their participation in extracellular matrix (ECM) stiffness. CD248 is a possible biomarker for non-small cell lung cancer (NSCLC)-derived CAFs, but its role in mediating ECM stiffness to promote NSCLC metastasis is unknown. We investigated the significance of CD248

Indexed as

Cancer-Associated FibroblastsCarcinoma, Non-Small-Cell LungConnective Tissue Growth FactorExtracellular MatrixHippo Signaling PathwayLung NeoplasmsMice, KnockoutProtein Serine-Threonine KinasesAnimalsAntigens, CDCell Line, TumorCell MovementGene Expression Regulation, NeoplasticHumansMiceNeoplasm MetastasisAntigens, CDCCN2 protein, humanConnective Tissue Growth FactorProtein Serine-Threonine Kinasescancer‐associated fibroblastsCD248extracellular matrix stiffnesshippo pathwaymetastasisnon‐small cell lung cancer

Identifiers

PMID39164826
PMCPMC11335579

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.